Inscrição na biblioteca: Guest
Portal Digital Begell Biblioteca digital da Begell eBooks Diários Referências e Anais Coleções de pesquisa
Critical Reviews™ in Biomedical Engineering
SJR: 0.207 SNIP: 0.376 CiteScore™: 0.79

ISSN Imprimir: 0278-940X
ISSN On-line: 1943-619X

Volumes:
Volume 47, 2019 Volume 46, 2018 Volume 45, 2017 Volume 44, 2016 Volume 43, 2015 Volume 42, 2014 Volume 41, 2013 Volume 40, 2012 Volume 39, 2011 Volume 38, 2010 Volume 37, 2009 Volume 36, 2008 Volume 35, 2007 Volume 34, 2006 Volume 33, 2005 Volume 32, 2004 Volume 31, 2003 Volume 30, 2002 Volume 29, 2001 Volume 28, 2000 Volume 27, 1999 Volume 26, 1998 Volume 25, 1997 Volume 24, 1996 Volume 23, 1995

Critical Reviews™ in Biomedical Engineering

DOI: 10.1615/CritRevBiomedEng.2014010687
pages 515-532

Factors Determining Airway Caliber in Asthma

Brian C. Harvey
Department of Biomedical Engineering, Boston University, Boston, Massachusetts
Kenneth R. Lutchen
Department of Biomedical Engineering, Boston University, Boston, Massachusetts

RESUMO

Airway hyperresponsiveness is a hallmark of asthma in which airways narrow excessively in response to an agonist, resulting in difficulty in breathing. Constriction of the smooth muscle that spirals around the airways is the principle cause of airway narrowing during an asthma attack. It is likely that several mechanisms are involved in the development of a hyperresponsive airway in asthma. In this review, we focus on the structural and functional aspects that govern the narrowing of a single airway within a lung, then we review the current understanding of how these factors become altered in a way that leads to the airway hyperresponsiveness observed in asthma. We first examine airway caliber as a simple equilibrium of forces favoring narrowing and the forces opposing this narrowing. We then review the role that the dynamic forces of tidal breathing and deep inspirations have across all length scales of the respiratory system; we describe an intriguing inconsistency that has arisen from these data. Finally, we examine the interaction between airway remodeling and inflammation and their roles in health and disease.


Articles with similar content:

Mechanical Determinants of Airways Hyperresponsiveness
Critical Reviews™ in Biomedical Engineering, Vol.39, 2011, issue 4
Jason H. T. Bates, Geoffrey N. Maksym
Computational Modeling of Airway and Pulmonary Vascular Structure and Function: Development of a "Lung Physiome"
Critical Reviews™ in Biomedical Engineering, Vol.39, 2011, issue 4
Merryn Tawhai, A. R. Clark, K. S. Burrowes, G. M. Donovan
Emergent Structure-Function Relations in Emphysema and Asthma
Critical Reviews™ in Biomedical Engineering, Vol.39, 2011, issue 4
Bela Suki, Tilo Winkler
The Biomechanics of ACL Injury: Progresses toward Prophylactic Strategies
Critical Reviews™ in Biomedical Engineering, Vol.41, 2013, issue 4-5
Chen-Hua Yeow, Luis Carlos Hernandez Barraza, Jin-Huat Low, Gokula Krishnan. R
Expression Patterns and Regulation of Glutamate Transporters in the Developing and Adult Nervous System
Critical Reviews™ in Neurobiology, Vol.13, 1999, issue 2
Karen D. Sims, Michael B. Robinson