Inscrição na biblioteca: Guest
Portal Digital Begell Biblioteca digital da Begell eBooks Diários Referências e Anais Coleções de pesquisa
Critical Reviews™ in Biomedical Engineering
SJR: 0.26 SNIP: 0.375 CiteScore™: 1.4

ISSN Imprimir: 0278-940X
ISSN On-line: 1943-619X

Volumes:
Volume 48, 2020 Volume 47, 2019 Volume 46, 2018 Volume 45, 2017 Volume 44, 2016 Volume 43, 2015 Volume 42, 2014 Volume 41, 2013 Volume 40, 2012 Volume 39, 2011 Volume 38, 2010 Volume 37, 2009 Volume 36, 2008 Volume 35, 2007 Volume 34, 2006 Volume 33, 2005 Volume 32, 2004 Volume 31, 2003 Volume 30, 2002 Volume 29, 2001 Volume 28, 2000 Volume 27, 1999 Volume 26, 1998 Volume 25, 1997 Volume 24, 1996 Volume 23, 1995

Critical Reviews™ in Biomedical Engineering

DOI: 10.1615/CritRevBiomedEng.2018025818
pages 53-82

Facilitating Earlier Diagnosis of Cardiovascular Disease through Point-of-Care Biosensors: A Review

Mackenzie M. Honikel
School of Biological and Health Systems Engineering, Arizona State University, Tempe, Arizona
Chi-En Lin
School of Biological and Health Systems Engineering, Arizona State University, Tempe, Arizona
David Probst
School of Biological and Health Systems Engineering, Arizona State University, Tempe, Arizona
Jeffrey T. La Belle
School of Biological and Health Systems Engineering, Arizona State University, Tempe, Arizona

RESUMO

Cardiovascular disease (CVD) accounts for 30% of all global deaths and is predicted to dominate in the coming years, despite vast improvements in medical technology. Current clinical methods of assessing an individual's cardiovascular health include blood tests to monitor relevant biomarker levels as well as varying imaging modalities such as electrocardiograms, computed tomography, and angiograms to assess vasculature. As informative as these tools are, they each require lengthy scheduling, preparation, and highly trained personnel to interpret the results before any information is accessible to patients, often leading to delayed treatment, which can be fatal. A point-of-care (POC) sensor platform is thus paramount in rapid and early diagnosis of CVD. Among the many POC detection platforms, including established optical and mechanical methods, electrochemical-based detection mechanisms have become increasingly desirable because of their superior sensitivity, low cost, and label-free detection. Specifically, electrochemical impedance spectroscopy (EIS) has demonstrated remarkable abilities in low-level (femtomolar) detection of several clinically useful biomarkers and has been reported in CVD diagnostic applications. In this review, we provide an in-depth overview of prevalent CVD diseases and clinically relevant proteomic biomarkers for assessing them. Subsequently, we discuss the ongoing development of POC sensors for CVD, highlighting the current clinical gold standard, potential alternative modalities, and electrochemical methodologies previously successful in quantifying specific biomarkers approved by the Food and Drug Administration (FDA). A discussion of EIS highlighting the attributes and capabilities of novel analysis algorithms is included to showcase the possibility of simultaneous dual-marker detection.


Articles with similar content:

Development Toward a Triple-Marker Biosensor for Diagnosing Cardiovascular Disease
Critical Reviews™ in Biomedical Engineering, Vol.47, 2019, issue 2
David Probst, Maryam Alsuwailem, Anna Deng, Theresa Broniak, Daniel Matloff, Jeffrey T. La Belle, Chi-En Lin
An Experimental Platform for Characterizing Cancer Biomarkers with Capabilities in Noninvasive and Continuous Screening
Critical Reviews™ in Biomedical Engineering, Vol.47, 2019, issue 3
Mackenzie M. Honikel, Jeffrey T. La Belle
Biomarkers for Serum Diagnosis of Infectious Diseases and Their Potential Application in Novel Sensor Platforms
Critical Reviews™ in Immunology, Vol.30, 2010, issue 2
Ana Graci Brito-Madurro, Carlos U. Vieira, Juliana F. Almeida, Luiz R. Goulart, Isabela M.B. Goulart, Ana Paula P. Freschi, Lucas F. Ferreira, Joao M. Madurro, Patricia T. Fujimura, Fausto E. Capparelli
Plasma Separation from Blood: The 'Lab-on-a-Chip' Approach
Critical Reviews™ in Biomedical Engineering, Vol.37, 2009, issue 6
Tae Goo Kang, Sangho Kim, Shatanik Mukherjee, Yu Chen
Liquid Biopsies in the Management of Bladder Cancer: Next-Generation Biomarkers for Diagnosis, Surveillance, and Treatment-Response Prediction
Critical Reviews™ in Oncogenesis, Vol.22, 2017, issue 5-6
Monica Cheng, Hristos Z. Kaimakliotis, Shaobo Zhang, Catherine R. Miller, Antonio Lopez-Beltran, Michael O. Koch, Yu Yang, Rodolfo Montironi, Liang Cheng