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Critical Reviews™ in Biomedical Engineering

Publicou 6 edições por ano

ISSN Imprimir: 0278-940X

ISSN On-line: 1943-619X

SJR: 0.262 SNIP: 0.372 CiteScore™:: 2.2 H-Index: 56

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An Experimental Platform for Characterizing Cancer Biomarkers with Capabilities in Noninvasive and Continuous Screening

Volume 47, Edição 3, 2019, pp. 217-234
DOI: 10.1615/CritRevBiomedEng.2019026426
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RESUMO

Early detection is crucial to the proper and effective treatment of two metastatic cancers, prostate cancer and small cell lung cancer. Currently, preventative screenings for these conditions are restricted to high-risk populations and extremely expensive. The discovery of clinically indicative biomarkers has been revolutionary in advancing screening and diagnostic capabilities. Prostate-specific antigen (PSA), an extracellular secreted protein of the prostate gland, and neuron-specific enolase (NSE), an enzyme of neuronal origin, have reported reputable specificity for prostate cancer and small cell lung cancer (SCLC). Current efforts are underway to develop a rapid, label-free means of measuring both PSA and NSE levels in a clinical environment for early screening applications of highly metastatic cancers. Electrochemical impedance spectroscopy (EIS) and impedance time (Z-t) are rapid, sensitive electrochemical techniques previously validated in the detection of several clinically relevant biomarkers, including cardiovascular disease and diabetes mellitus. Herein, we determine the optimal frequencies of PSA (81.38 Hz) and NSE (14.36 Hz) using EIS that are robust across analytical platforms and in the presence of potentially interfering species. The reported empirical evidence supports the prevalence of electrostatic interactions in electrochemical systems and provides alternative theoretical support of previous findings. Finally, Z-t was implemented for its utility in continuous monitoring applications and to lay the foundation for future improvements to continuous sensor platforms.

CITADO POR
  1. Pauliukaite Rasa, Voitechovič Edita, Multisensor Systems and Arrays for Medical Applications Employing Naturally-Occurring Compounds and Materials, Sensors, 20, 12, 2020. Crossref

  2. Strong Madison E., Richards Jeffrey R., Torres Manuel, Beck Connor M., La Belle Jeffrey T., Faradaic electrochemical impedance spectroscopy for enhanced analyte detection in diagnostics, Biosensors and Bioelectronics, 177, 2021. Crossref

  3. Borumand Mehrasa Rahimi, Babaloii Fatemeh, Mirmotahari Seyedeh Azin, Maghsoudi Armin Salek, Torabi Raheleh, Mojtahedzadeh Mojtaba, Norouzi Parviz, Rad-Malekshahi Mazda, Javar Hamid Akbari, Hassani Shokoufeh, Recent trends and innovations in biosensors development for biomarkers towards monitoring traumatic brain injury, Biosensors and Bioelectronics: X, 12, 2022. Crossref

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