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Critical Reviews™ in Biomedical Engineering

Publicou 6 edições por ano

ISSN Imprimir: 0278-940X

ISSN On-line: 1943-619X

SJR: 0.262 SNIP: 0.372 CiteScore™:: 2.2 H-Index: 56

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Establishing Early Functional Perfusion and Structure in Tissue Engineered Cardiac Constructs

Volume 43, Edição 5-6, 2015, pp. 455-471
DOI: 10.1615/CritRevBiomedEng.2016016066
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RESUMO

Myocardial infarction (MI) causes massive heart muscle death and remains a leading cause of death in the world. Cardiac tissue engineering aims to replace the infarcted tissues with functional engineered heart muscles or revitalize the infarcted heart by delivering cells, bioactive factors, and/or biomaterials. One major challenge of cardiac tissue engineering and regeneration is the establishment of functional perfusion and structure to achieve timely angiogenesis and effective vascularization, which are essential to the survival of thick implants and the integration of repaired tissue with host heart. In this paper, we review four major approaches to promoting angiogenesis and vascularization in cardiac tissue engineering and regeneration: delivery of pro-angiogenic factors/molecules, direct cell implantation/cell sheet grafting, fabrication of prevascularized cardiac constructs, and the use of bioreactors to promote angiogenesis and vascularization. We further provide a detailed review and discussion on the early perfusion design in nature-derived biomaterials, synthetic biodegradable polymers, tissue-derived acellular scaffolds/whole hearts, and hydrogel derived from extracellular matrix. A better understanding of the current approaches and their advantages, limitations, and hurdles could be useful for developing better materials for future clinical applications.

CITADO POR
  1. Tang-Quan Karis R., Mehta Nicole A., Sampaio Luiz C., Taylor Doris A., Whole Cardiac Tissue Bioscaffolds, in Cardiac Extracellular Matrix, 1098, 2018. Crossref

  2. Fan Zhaobo, Xu Zhaobin, Niu Hong, Gao Ning, Guan Ya, Li Chao, Dang Yu, Cui Xiaoyu, Liu Xuanyou Liu, Duan Yunyan, Li Haichang, Zhou Xinyu, Lin Pei-Hui, Ma Jianjie, Guan Jianjun, An Injectable Oxygen Release System to Augment Cell Survival and Promote Cardiac Repair Following Myocardial Infarction, Scientific Reports, 8, 1, 2018. Crossref

  3. Edri Reuven, Gal Idan, Noor Nadav, Harel Tom, Fleischer Sharon, Adadi Nofar, Green Ori, Shabat Doron, Heller Lior, Shapira Assaf, Gat-Viks Irit, Peer Dan, Dvir Tal, Personalized Hydrogels for Engineering Diverse Fully Autologous Tissue Implants, Advanced Materials, 31, 1, 2019. Crossref

  4. An Yang, Reimers Kerstin, Allmeling Christina, Liu Jieli, Lazaridis Andrea, Strauss Sarah, Vogt Peter M., Large-Volume Vascularized Muscle Grafts Engineered From Groin Adipose Tissue in Perfusion Bioreactor Culture, Journal of Craniofacial Surgery, 31, 2, 2020. Crossref

  5. Shchotkina Nataliia, Aspects of Lyophilization of Cardiac Bioimplant, Innovative Biosystems and Bioengineering, 5, 4, 2021. Crossref

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