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Critical Reviews™ in Biomedical Engineering
SJR: 0.207 SNIP: 0.376 CiteScore™: 0.79

ISSN Imprimir: 0278-940X
ISSN On-line: 1943-619X

Volume 47, 2019 Volume 46, 2018 Volume 45, 2017 Volume 44, 2016 Volume 43, 2015 Volume 42, 2014 Volume 41, 2013 Volume 40, 2012 Volume 39, 2011 Volume 38, 2010 Volume 37, 2009 Volume 36, 2008 Volume 35, 2007 Volume 34, 2006 Volume 33, 2005 Volume 32, 2004 Volume 31, 2003 Volume 30, 2002 Volume 29, 2001 Volume 28, 2000 Volume 27, 1999 Volume 26, 1998 Volume 25, 1997 Volume 24, 1996 Volume 23, 1995

Critical Reviews™ in Biomedical Engineering

DOI: 10.1615/CritRevBiomedEng.2019030527
pages 365-378

Potential Applications of Silk Fibroin as Vascular Implants: A Review

Melissa Puerta
Grupo de Investigación sobre Nuevos Materiales (GINUMA), Escuela de Ingeniería, and Grupo de Dinámica Cardiovascular (GDC), Escuela de Ciencias de la Salud, Universidad Pontificia Bolivariana, Circular 1ra #70-01, 0500031, Medellín, Antioquia, Colombia
Y. Montoya
Grupo de Investigación sobre Nuevos Materiales (GINUMA), Escuela de Ingeniería, and Grupo de Dinámica Cardiovascular (GDC), Escuela de Ciencias de la Salud, Universidad Pontificia Bolivariana, Circular 1ra #70-01, 0500031, Medellín, Antioquia, Colombia
J. Bustamante
Grupo de Investigación sobre Nuevos Materiales (GINUMA), Escuela de Ingeniería, and Grupo de Dinámica Cardiovascular (GDC), Escuela de Ciencias de la Salud, Universidad Pontificia Bolivariana, Circular 1ra #70-01, 0500031, Medellín, Antioquia, Colombia
A. Restrepo-Osorio
Grupo de Investigación sobre Nuevos Materiales (GINUMA), Escuela de Ingeniería, and Grupo de Dinámica Cardiovascular (GDC), Escuela de Ciencias de la Salud, Universidad Pontificia Bolivariana, Circular 1ra #70-01, 0500031, Medellín, Antioquia, Colombia


Cardiovascular disease is a worldwide main cause of morbidity and mortality. Treatment alternatives include the use of cardiovascular implants that have generated a constant search for materials, and transformation processes that provide structures similar to those that need to be replaced. Among the biomaterials available for vascular implants, silk fibroin (SF) is of great interest because it is a natural, biodegradable, biocompatible protein. In addition, SF has outstanding mechanical properties and can be easily processed by various techniques. This article presents a general review of SF, its potential use as a biomaterial for vascular applications, and modifications that improve its hemocompatibility.


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