Publicou 6 edições por ano
ISSN Imprimir: 0278-940X
ISSN On-line: 1943-619X
Indexed in
Magnetic Resonance Characterization of Tissue Engineered Cartilage via Changes in Relaxation Times, Diffusion Coefficient, and Shear Modulus
RESUMO
The primary goal of this paper is to describe a combined MR relaxation (T2 and T1ρ), diffusion (apparent diffusion coefficient [ADC]), and elastography (shear stiffness) method of fully characterizing the development of tissue-engineered cartilage in terms of the changes in its composition, structure, and mechanical properties during tissue growth. Then, we may better use MR-based methodologies to noninvasively monitor and optimize the cartilage tissue engineering process without sacrificing the constructs. This process begins by demonstrating the potential capability of T2, T1ρ, ADC, and shear stiffness in characterizing a scaffold-free engineered cartilage. The results show that, in addition to the conventional T2 and ADC, T1ρ and MRE can be used as potential biomarkers to assess the specific changes in proteoglycan content and mechanical properties of engineered cartilage during culture. Moreover, to increase the efficiency of MR characterization, two new methodologies for simultaneous acquisition of diffusion and MRE (dMRE), and T1ρ and MRE (T1ρ-MRE) are introduced that allow the simultaneous characterization of both biochemical and mechanical properties of engineered cartilage tissue. The feasibilities of dMRE and T1ρ-MRE approaches are validated on tissue-mimicking phantoms. The results show good correspondence between simultaneous acquisitions and conventional separate acquisition methods.
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Majumdar Shreyan, Pothirajan Padmabharathi, Dorcemus Deborah, Nukavarapu Syam, Kotecha Mrignayani, High Field Sodium MRI Assessment of Stem Cell Chondrogenesis in a Tissue-Engineered Matrix, Annals of Biomedical Engineering, 44, 4, 2016. Crossref
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Yin Ziying, Kearney Steven P., Magin Richard L., Klatt Dieter, Concurrent 3D acquisition of diffusion tensor imaging and magnetic resonance elastography displacement data ( DTI‐MRE ): Theory and in vivo application , Magnetic Resonance in Medicine, 77, 1, 2017. Crossref
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Kotecha Mrignayani, Magnetic resonance imaging monitoring of cartilage tissue engineering in vivo, in Monitoring and Evaluation of Biomaterials and their Performance In Vivo, 2017. Crossref
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Kotecha Mrignayani, Principles and Applications of Quantitative Parametric MRI in Tissue Engineering, in Magnetic Resonance Imaging in Tissue Engineering, 2017. Crossref
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Kotecha Mrignayani, Magin Richard L., MRI Assessment of Engineered Cartilage Tissue Growth, in Magnetic Resonance Imaging in Tissue Engineering, 2017. Crossref