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Plasma Medicine
SJR: 0.198 SNIP: 0.183 CiteScore™: 0.57

ISSN Imprimir: 1947-5764
ISSN On-line: 1947-5772

Plasma Medicine

DOI: 10.1615/PlasmaMed.2016015761
pages 237-247

Using Helium-Generated Cold Plasma to Control Infection and Healing

Paola Brun
Dipartimento di Medicina Molecolare, Unità di Microbiologia, Università di Padova, Italy
Venera Russo
Department of Molecular Medicine, University of Padova, Unit of Microbiology, I-35100 Padua, Italy
Elena Tarricone
Department of Molecular Medicine, University of Padova, Unit of Histology, I-35100 Padua, Italy
Simona Corrao
Department of Molecular Medicine, University of Padova, Unit of Histology, I-35100 Padua, Italy
Velika Deligianni
Department of Ophthalmology, San Antonio Hospital, I-35100 Padua, Italy
Andrea Leonardi
Department of Neuroscience, University of Padova, Unit of Ophthalmology, I-35100 Padua, Italy
Roberto Cavazzana
Consorzio RFX, Padova, Italy
Matteo Zuin
Consorzio RFX, Padova, Italy
Emilio Martines
Consorzio RFX, Padova, Italy


Cold atmospheric pressure plasma has been proposed for sterilization of inert surfaces and disinfection of living tissues. Our recent studies reveal that chemically active species such as reactive oxygen species generated by a low-power atmospheric pressure nonthermal plasma source obtained by ionizing helium gas mixed with ambient air are mandatory for their antimicrobial effects. In addition, they also initiate intracellular signaling pathways required for wound healing in eukaryotic cells. Thus, exposure to plasma sustains healing of tissue injuries both indirectly through microbicidal effects and directly by action on cells such as fibroblasts involved in tissue regeneration.

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