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Plasma Medicine
SJR: 0.271 SNIP: 0.316 CiteScore™: 1.9

ISSN Imprimir: 1947-5764
ISSN On-line: 1947-5772

Plasma Medicine

DOI: 10.1615/PlasmaMed.2018023951
pages 35-44

Radio-Frequency Plasma-Induced Biocompatibility of Polyimide Substrates

Magdaleno R. Vasquez, Jr.
Department of Mining, Metallurgical, and Materials Engineering, College of Engineering, University of the Philippines, Diliman, Quezon City 1101, The Philippines
Eloise I. Prieto
National Institute of Molecular Biology and Biotechnology, College of Science, University of the Philippines, Diliman, Quezon City 1101, Philippines
Motoi Wada
Graduate School of Science and Engineering, Doshisha University, Kyotanabe, Kyoto 610-0321, Japan


Surfaces of polyimide (PI) sheets were modified using 13.56-MHz radio-frequency discharges to enhance their affinity with fibroblast cells. Physico-chemical analysis of pristine and plasma-treated PI sheets showed different responses against argon (Ar), oxygen (O2), and nitrogen (N2) as the plasma process gases. Overall, hydrophilicity of treated PI surfaces was enhanced, and its surface free energy increased from 53 dyn/cm to at least 73 dyn/ cm. Surface roughness values also increased from 1.3 to 40.8 nm, as demonstrated by atomic force microscopy analyses. Infrared spectral analyses showed a decrease of imide functional group peak intensities on plasma exposure, corresponding to chemical surface structural changes. In addition, plasma-treated surfaces significantly increased cell adhesion and proliferation compared to pristine samples. N2-containing plasma exhibited the greatest increase among the test gases, due to the possible inclusion of N2-based functional groups that enhance biochemical affinity of fibroblast cells.

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