Inscrição na biblioteca: Guest
Portal Digital Begell Biblioteca digital da Begell eBooks Diários Referências e Anais Coleções de pesquisa
Plasma Medicine
SJR: 0.278 SNIP: 0.183 CiteScore™: 0.57

ISSN Imprimir: 1947-5764
ISSN On-line: 1947-5772

Plasma Medicine

DOI: 10.1615/PlasmaMed.2013006218
pages 71-83

Deep Penetration into Tissues of Reactive Oxygen Species Generated in Floating-Electrode Dielectric Barrier Discharge (FE-DBD): An In Vitro Agarose Gel Model Mimicking an Open Wound

Danil Dobrynin
C&J Nyheim Plasma Institute, Drexel University, Camden NJ 08103
Gregory Fridman
C&J Nyheim Plasma Institute, Drexel University, Camden, New Jersey 08103
Gary Friedman
Department of Electrical and Computer Engineering, College of Engineering, A. J. Drexel Plasma Institute, Drexel University, Philadelphia, Pennsylvania
Alexander A. Fridman
C&J Nyheim Plasma Institute, Drexel University, Camden, New Jersey 08103


In this article we present an in vitro model based on agarose gel that can be used to simulate a dirty, oily, bloody, and morphologically complex surface of, for example, an open wound. We show this model's effectiveness in simulating the depth of penetration of reactive species generated in plasma (e.g., hydrogen peroxide) deep into the tissue of a rat and confirm the penetration depths using an agarose gel model. We envision that such a model could be used in the future to study plasma discharges (and other modalities) and minimize the use of live animals; plasma can be optimized on the agarose gel wound model and then finally verified using an actual wound.

Articles with similar content:

Comparison of Extraction of Valuable Compounds from Microalgae by Atmospheric Pressure Plasmas and Pulsed Electric Fields
Plasma Medicine, Vol.6, 2016, issue 3-4
Michael Schmidt, Christian Schulze, Juergen F. Kolb, Wolfgang Frey, Katja Zocher, Jana Kredl, Tilo Schulz, Sabine Mundt, Camelia Miron, Robert Banaschik
Comparative Study between Direct and Indirect Treatment with Cold Atmospheric Plasma on In Vitro and In Vivo Models of Wound Healing
Plasma Medicine, Vol.8, 2018, issue 4
Jean-Jacques Lataillade, Constance Duchesne, Nadira Frescaline, Antoine Rousseau
Acute Rat Cutaneous Wound Healing for Small and Large Wounds Using Ar/O2 Atmospheric-Pressure Plasma Jet Treatment
Plasma Medicine, Vol.7, 2017, issue 3
Jong-Shinn Wu, Chen-Yon Tobias Tschang, Yu-Pin Cheng, Bi-Ren Gu, Zhi-Hua Lin, Kou-Chi Liao, Kuang-Yao Cheng, Nai-Lun Yeh, Hsien-Yi Chiu
Fast Blood Coagulation of Capillary Vessels by Cold Plasma: A Rat Ear Bleeding Model
Plasma Medicine, Vol.1, 2011, issue 3-4
Gregory Fridman, Danil Dobrynin, Kimberly Wasko, Alexander A. Fridman, Gary Friedman
Treatment of Microorganisms in Vegetables and Fruits by Gliding Arc
Plasma Medicine, Vol.4, 2014, issue 1-4
Mohamed El Shaer, M. Mobasher, A. Abdelghany