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Plasma Medicine
SJR: 0.271 SNIP: 0.316 CiteScore™: 1.9

ISSN Imprimir: 1947-5764
ISSN On-line: 1947-5772

Plasma Medicine

DOI: 10.1615/PlasmaMed.2018020991
pages 163-175

Electromagnetic Fields Induce Frequency-Dependent Radioprotection and Radiosensitization in In Vitro Cell Cultures

Angela Chinhengo
Division of Radiobiology, Department of Medical Imaging and Clinical Oncology, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg 7505, South Africa
Antonio Serafin
Division of Radiobiology, Department of Medical Imaging and Clinical Oncology, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg 7505, South Africa
Bianca Hamman
Division of Radiobiology, Department of Medical Imaging and Clinical Oncology, Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa
John Akudugu
Division of Radiobiology, Department of Medical Imaging and Clinical Oncology, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg 7505, South Africa

RESUMO

The incidence of Kaposi sarcoma comorbidity in patients with human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) is high. These patients tend to be more sensitive to ionizing radiation, making the management of their cancer with radiotherapy difficult. Hence, noninvasive methods to sensitize cancer cells and reduce therapeutic doses are needed. In this article, the effect of an electromagnetic field (EMF) of 27.125 MHz, modulated by 100- and 1000-Hz fields, on the radiosensitivity of Chinese hamster lung fibroblasts (V79) and human melanoma cells (MeWo) was evaluated using the colony-forming assay. Induced magnetic flux densities in cell cultures ranged from 0.05 to 0.25 μT. Preexposure of V79 to both modulated fields had no effect on their radiosensitivity, if irradiation followed within 2 h or at 6 h. Significant radiosensitization was observed when X-rays were administered 4 h after EMF exposure. Preexposure of MeWo to the 100-Hz-modulated field resulted in a significant radioprotection when irradiation followed within 6 h. However, treatment of these cells with the 1000-Hz-modulated field significantly potentiated the effect of X-rays. When cells were irradiated before EMF exposure, V79 cells were marginally protected by the 100-Hz-modulated field and sensitized by the 1000-Hz-modulated field. In contrast, the melanoma cells were slightly protected by the 1000-Hz-modulated field and sensitized by the 100-Hz-modulated field. Informed combination of low-medium frequency electromagnetic fields and radiotherapy might be beneficial in cancer management, especially in HIV-positive patients.


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