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Critical Reviews™ in Eukaryotic Gene Expression

Publicou 6 edições por ano

ISSN Imprimir: 1045-4403

ISSN On-line: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

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Apoptosis in Membranous Bone Formation: Role of Fibroblast Growth Factor and Bone Morphogenetic Protein Signaling

Volume 15, Edição 1, 2005, pp. 75-92
DOI: 10.1615/CritRevEukaryotGeneExpr.v15.i1.50
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RESUMO

Membranous ossification occurs by the condensation of mesenchymal cells followed by their progressive differentiation into osteoblasts that form a mineralized matrix in ossification centers. The balance between proliferating and differentiated osteogenic cells at the suture areas between calvarial bones is essential for the control of suture maintenance and membranous bone formation. The mechanisms of regulation of cell apoptosis in suture areas begin to be understood. Fibroblast growth factor (FGF) and bone morphogenetic protein (BMP) are important regulators of mesenchymal, preosteoblast, and osteoblast apoptosis in suture areas. Perturbations in FGF or BMP signaling lead to alter the number of apoptotic osteogenic cells, resulting in premature or delayed suture closure. Recent data indicate that FGF signaling downregulates preosteoblast apoptosis, thereby preventing premature fusion of adjacent mineralizing extremities. In contrast, continuous FGF signaling or constitutive FGF receptor activation, as well as BMP signaling, upregulate osteoblast apoptosis. Additionally, multiple signaling mechanisms, including PI3K and PKC, appear to be involved in the control of calvarial osteoblast apoptosis by FGF and BMP. These mechanisms allow a fine control of the number of functional bone-forming cells and, thereby, the normal progression of membranous bone formation.

CITADO POR
  1. Fromigué Olivia, Haÿ Eric, Barbara Alain, Petrel Christophe, Traiffort Elisabeth, Ruat Martial, Marie Pierre J., Calcium sensing receptor‐dependent and receptor‐independent activation of osteoblast replication and survival by strontium ranelate, Journal of Cellular and Molecular Medicine, 13, 8b, 2009. Crossref

  2. Shapiro Irving M., Adams Christopher S., Freeman Theresa, Srinivas Vickram, Fate of the hypertrophic chondrocyte: Microenvironmental perspectives on apoptosis and survival in the epiphyseal growth plate, Birth Defects Research Part C: Embryo Today: Reviews, 75, 4, 2005. Crossref

  3. Hurley Marja M., Naski Michael, Marie Pierre J., Fibroblast Growth Factor (FGF) and FGF Receptor Families in Bone, in Principles of Bone Biology, 2008. Crossref

  4. Zhu Xiao, Jiang Yi, Shan Peng-Fei, Shen Jie, Liang Qiu-Hua, Cui Rong-Rong, Liu Yuan, Liu Guan-Ying, Wu Shan-Shan, Lu Qiong, Xie Hui, Liu You-Shuo, Yuan Ling-Qing, Liao Er-Yuan, Vaspin attenuates the apoptosis of human osteoblasts through ERK signaling pathway, Amino Acids, 44, 3, 2013. Crossref

  5. Li P.F., Zhou Z.L., Shi C.Y., Hou J.F., Downregulation of basic fibroblast growth factor is associated with femoral head necrosis in broilers, Poultry Science, 94, 5, 2015. Crossref

  6. References, in Bones and Cartilage, 2015. Crossref

  7. Yang M., Yuan H., Miao M., Xu W., The osteogenic potential of ligament fibroblasts is greater in ankylosing spondylitis patients than in patients with osteoarthritis, Zeitschrift für Rheumatologie, 74, 4, 2015. Crossref

  8. Mishina Yuji, Kamiya Nobuhiro, Embryonic Skeletogenesis and Craniofacial Development, in Bone Morphogenetic Proteins: Systems Biology Regulators, 2017. Crossref

  9. Marie Pierre J., FGF/FGFR Signaling in Skeletal Dysplasias, in Bone and Development, 2010. Crossref

  10. Estrada Kristine D., Lyons Karen M., BMP Signaling in Skeletogenesis, in Bone and Development, 2010. Crossref

  11. Ornitz David M., Marie Pierre J., Fibroblast growth factor signaling in skeletal development and disease, Genes & Development, 29, 14, 2015. Crossref

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