Inscrição na biblioteca: Guest
Portal Digital Begell Biblioteca digital da Begell eBooks Diários Referências e Anais Coleções de pesquisa
Critical Reviews™ in Eukaryotic Gene Expression
Fator do impacto: 2.156 FI de cinco anos: 2.255 SJR: 0.649 SNIP: 0.599 CiteScore™: 3

ISSN Imprimir: 1045-4403
ISSN On-line: 2162-6502

Volumes:
Volume 30, 2020 Volume 29, 2019 Volume 28, 2018 Volume 27, 2017 Volume 26, 2016 Volume 25, 2015 Volume 24, 2014 Volume 23, 2013 Volume 22, 2012 Volume 21, 2011 Volume 20, 2010 Volume 19, 2009 Volume 18, 2008 Volume 17, 2007 Volume 16, 2006 Volume 15, 2005 Volume 14, 2004 Volume 13, 2003 Volume 12, 2002 Volume 11, 2001 Volume 10, 2000 Volume 9, 1999 Volume 8, 1998 Volume 7, 1997 Volume 6, 1996 Volume 5, 1995 Volume 4, 1994

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v21.i1.30
pages 29-41

Notochordal Cells in the Adult Intervertebral Disc: New Perspective on an Old Question

Makarand V. Risbud
Department of Orthopaedic Surgery and Graduate Program in Tissue Engineering and Regenerative Medicine, Thomas Jefferson University, Philadelphia, PA, USA
Irving M. Shapiro
Department of Orthopaedic Surgery and Graduate Program in Tissue Engineering and Regenerative Medicine, Thomas Jefferson University, Philadelphia, PA, USA

RESUMO

The intervertebral disc is a tissue positioned between each of the vertebrae that accommodates applied biomechanical forces to the spine. The central compartment of the disc contains the nucleus pulposus (NP) which is enclosed by the annulus fibrosus and the endplate cartilage.The NP is derived from the notochord, a rod-like structure of mesodermal origin. Development of the notochord is tightly regulated by interactive transcription factors and target genes. Since a number of these molecules are unique they have be used for cell lineage and fate mapping studies of tissues of the intervertebral disc. These studies have shown that in a number of species including human, NP tissue retains notochordal cells throughout life. In the adult NP, there are present both large and small notochordal cells, as well as a progenitor cell population which can differentiate along the mesengeic pathway. Since tissue renewal in the intervertebral disc is dependent on the ability of these cells to commit to the NP lineage and undergo terminal differentiation, studies have been performed to assess which signaling pathways may regulate these activities. The notch signaling pathway is active in the intervertebral disc and is responsive to hypoxia, probably through HIF-1a. From a disease viewpoint, it is hypothesized that an oxemic shift, possibly mediated by alterations in the vascular supply to the tissues of the disc would be expected to lead to a failure in notochordal progenitor cell activation and a decrease in the number of differentiated cells. In turn, this would lead to decrements in function and enhancement of the effect of agents that are known to promote disc degeneration.


Articles with similar content:

Brain Lipoprotein Metabolism and Its Relation to Neurodegenerative Disease
Critical Reviews™ in Neurobiology, Vol.13, 1999, issue 4
Marc Danik, Uwe Beffert, Danielle Champagne, Caroline Petit-Turcotte, Judes Poirier
Mechanosensing and Mechanochemical Transduction: How Is Mechanical Energy Sensed and Converted Into Chemical Energy in an Extracellular Matrix?
Critical Reviews™ in Biomedical Engineering, Vol.31, 2003, issue 4
Lorraine M. Siperko, Frederick H. Silver
Stem Cell-Based Models and Therapies for Neurodegenerative Diseases
Critical Reviews™ in Biomedical Engineering, Vol.37, 2009, issue 4-5
Khaled Alsayegh, Sheena Abraham, Raj R. Rao, Shilpa Iyer
Mesenchymal Stem Cells in the Aging and Osteoporotic Population
Critical Reviews™ in Eukaryotic Gene Expression, Vol.21, 2011, issue 4
Milena Fini, Paola Torricelli, Francesca Veronesi, Matilde Tschon, Veronica Borsari, Lia Rimondini
Contribution of Phosphoinositide Signaling Pathway to Opioid-Mediated Control of P2X3 Receptors in the Primary Sensory Neurons
International Journal of Physiology and Pathophysiology, Vol.7, 2016, issue 3
Igor V. Chizhmakov, Oleg O. Krishtal, Vyacheslav B. Kulyk, Oleksandr P. Maximyuk, Tetyana M. Volkova