Publicou 6 edições por ano
ISSN Imprimir: 1045-4403
ISSN On-line: 2162-6502
Indexed in
Indirect and Direct Disruption of Transcriptional Regulation in Cancer: E2F and AML-1
RESUMO
The disruption of transcriptional regulatory circuits through the elimination of negative regulatory factors (tumor suppressors), the activation of positive acting factors (oncogenes), or when chimeric proteins result from chromosomal translocations, is likely a key event in multistep tumorigenesis. Here, using the transcription factors E2F and AML-1 as model systems, we discuss the disruption of coordinate transcriptional regulation in oncogenesis. E2F oncogenic signals are released when the pRb tumor suppressor is inactivated, and E2F activation may necessitate the coordinate inactivation of a second tumor suppressor, p53. AML-1 is the target of the (8;21) translocation, found in approximately 15% of acute myeloid leukemia (AML) cases, and the t(12;21), found in up to 30% of childhood B-cell acute lymphoblastic leukemias. The t(8;21) creates a fusion protein between AML-1 and a gene of unknown function, mtg8 (ETO), whereas the t(12:21) fuses the TEL (translocation-ets-leukemia) transcription factor to the N-terminus of AML-1. The inv(16), which is the most frequent anomaly found in AML, also targets AML-1, by fusing the gene that encodes AML-l's heterodimeric partner CBFβ to the smooth muscle myosin heavy chain gene MYH11. Thus, E2F and AML-1 provide excellent models for the disruption of transcriptional regulation in cancer.
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Robins Diane M, , 78, 2004. Crossref
-
McNeil Sandra, Guo Bo, Stein Janet L., Lian Jane B., Bushmeyer Sarah, Seto Edward, Atchison Michael L., Penman Sheldon, van Wijnen André J., Stein Gary S., Targeting of the YY1 transcription factor to the nucleolus and the nuclear matrix in situ: The C-terminus is a principal determinant for nuclear trafficking, Journal of Cellular Biochemistry, 68, 4, 1998. Crossref
-
Banerjee Chaitali, McCabe Laura R., Choi Je-Yong, Hiebert Scott W., Stein Janet L., Stein Gary S., Lian Jane B., Runt homology domain proteins in osteoblast differentiation: AML3/CBFA1 is a major component of a bone-specific complex, Journal of Cellular Biochemistry, 66, 1, 1997. Crossref
-
Lindenmuth Danielle M., van Wijnen Andre J., Hiebert Scott, Stein Janet L., Lian Jane B., Stein Gary S., Subcellular partitioning of transcription factors during osteoblast differentiation: Developmental association of the AML/CBFα/PEBP2α-related transcription factor-NMP-2 with the nuclear matrix, Journal of Cellular Biochemistry, 66, 1, 1997. Crossref
-
McNeil Sandra, Javed Amjad, Harrington Kimberly S., Lian Jane B., Stein Janet L., van Wijnen Andre J., Stein Gary S., Leukemia-associated AML1/ETO (8;21) chromosomal translocation protein increases the cellular representation of PML bodies, Journal of Cellular Biochemistry, 79, 1, 2000. Crossref
-
Schmitt John M., Hwang Kun, Winn Shelley R., Hollinger Jeffrey O., Bone morphogenetic proteins: An update on basic biology and clinical relevance, Journal of Orthopaedic Research, 17, 2, 1999. Crossref
-
Das Debopriya, Nahlé Zaher, Zhang Michael Q, Adaptively inferring human transcriptional subnetworks, Molecular Systems Biology, 2, 1, 2006. Crossref
-
Gordon Jeffrey A., Pockwinse Shirwin M., Stewart F. Marc, Quesenberry Peter J., Nakamura Tatsuya, Croce Carlo M., Lian Jane B., Stein Janet L., van Wijnen Andr� J., Stein Gary S., Modified intranuclear organization of regulatory factors in human acute leukemias: Reversal after treatment, Journal of Cellular Biochemistry, 77, 1, 2000. Crossref
-
Fenrick Randy, Hiebert Scott W., Role of histone deacetylases in acute leukemia, Journal of Cellular Biochemistry, 72, S30-31, 1998. Crossref
-
Bernard O. A., Romana S. P., Poirel H., Berger R., Molecular Cytogenetics of t(12;21)(p13;q22), Leukemia & Lymphoma, 23, 5-6, 1996. Crossref
-
Lutterbach B, Hiebert S.W, Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation, Gene, 245, 2, 2000. Crossref
-
Westendorf Jennifer J., Mernaugh Ray, Hiebert Scott W., Identification and characterization of a protein containing formin homology (FH1/FH2) domains, Gene, 232, 2, 1999. Crossref
-
Bushweller John H, CBF—A biophysical perspective, Seminars in Cell & Developmental Biology, 11, 5, 2000. Crossref
-
Berardi Marcelo J, Sun Chaohong, Zehr Michael, Abildgaard Frits, Peng Jeff, Speck Nancy A, Bushweller John H, The Ig fold of the core binding factor α Runt domain is a member of a family of structurally and functionally related Ig-fold DNA-binding domains, Structure, 7, 10, 1999. Crossref
-
Levanon Ditsa, Eisenstein Miriam, Groner Yoram, Site-directed mutagenesis supports a three-dimensional model of the runt domain 1 1Edited by A. Klug, Journal of Molecular Biology, 277, 3, 1998. Crossref
-
Shi Meng-Jiao, Park Seok-Rae, Kim Pyeung-Hyeun, Stavnezer Janet, Roles of Ets proteins, NF-κB and nocodazole in regulating induction of transcription of mouse germline Ig α RNA by transforming growth factor-β1, International Immunology, 13, 6, 2001. Crossref
-
Ramsey Jon, Butnor Kelly, Peng Zhihua, Leclair Tim, van der Velden Jos, Stein Gary, Lian Jane, Kinsey C. Matthew, Loss of RUNX1 is associated with aggressive lung adenocarcinomas, Journal of Cellular Physiology, 233, 4, 2018. Crossref
-
Lymar Elena S., Clark Ann M., Reeves Raymond, Griswold Michael D., Clusterin Gene in Rat Sertoli Cells Is Regulated by a Core-Enhancer Element, Biology of Reproduction, 63, 5, 2000. Crossref
-
Mahlknecht Ulrich, Hoelzer Dieter, Histone Acetylation Modifiers in the Pathogenesis of Malignant Disease, Molecular Medicine, 6, 8, 2000. Crossref
-
Stavnezer J., Molecular Processes that Regulate Class Switching, in Signal Transduction and the Coordination of B Lymphocyte Development and Function II, 245/2, 2000. Crossref
-
Guidez Fabien, Petrie Kevin, Ford Anthony M., Lu Huafeng, Bennett Caroline A., MacGregor Angus, Hannemann Jürgen, Ito Yoshiaki, Ghysdael Jacques, Greaves Mel, Wiedemann Leanne M., Zelent Arthur, Recruitment of the nuclear receptor corepressor N-CoR by the TEL moiety of the childhood leukemia–associated TEL-AML1 oncoprotein, Blood, 96, 7, 2000. Crossref
-
Guidez Fabien, Petrie Kevin, Ford Anthony M., Lu Huafeng, Bennett Caroline A., MacGregor Angus, Hannemann Jürgen, Ito Yoshiaki, Ghysdael Jacques, Greaves Mel, Wiedemann Leanne M., Zelent Arthur, Recruitment of the nuclear receptor corepressor N-CoR by the TEL moiety of the childhood leukemia–associated TEL-AML1 oncoprotein, Blood, 96, 7, 2000. Crossref
-
Ernst Patricia, Hematopoietic Stem Cells, in Molecular Basis of Hematopoiesis, 2009. Crossref
-
Melnick Ari, Carlile Graeme W., McConnell Melanie J., Polinger Adam, Hiebert Scott W., Licht Jonathan D., AML-1/ETO fusion protein is a dominant negative inhibitor of transcriptional repression by the promyelocytic leukemia zinc finger protein, Blood, 96, 12, 2000. Crossref
-
Melnick Ari, Carlile Graeme W., McConnell Melanie J., Polinger Adam, Hiebert Scott W., Licht Jonathan D., AML-1/ETO fusion protein is a dominant negative inhibitor of transcriptional repression by the promyelocytic leukemia zinc finger protein, Blood, 96, 12, 2000. Crossref
-
Banerjee Chaitali, Javed Amjad, Choi Je-Yong, Green Jack, Rosen Vicki, van Wijnen André J., Stein Janet L., Lian Jane B., Stein Gary S., Differential Regulation of the Two Principal Runx2/Cbfa1 N-Terminal Isoforms in Response to Bone Morphogenetic Protein-2 during Development of the Osteoblast Phenotype, Endocrinology, 142, 9, 2001. Crossref
-
Crute Barbara E., Lewis Amy F., Wu Zining, Bushweller John H., Speck Nancy A., Biochemical and Biophysical Properties of the Core-binding Factor α2 (AML1) DNA-binding Domain, Journal of Biological Chemistry, 271, 42, 1996. Crossref
-
Tang Lei, Guo Bo, Javed Amjad, Choi Je-Yong, Hiebert Scott, Lian Jane B., van Wijnen André J., Stein Janet L., Stein Gary S., Zhou G. Wayne, Crystal Structure of the Nuclear Matrix Targeting Signal of the Transcription Factor Acute Myelogenous Leukemia-1/Polyoma Enhancer-binding Protein 2αB/Core Binding Factor α2, Journal of Biological Chemistry, 274, 47, 1999. Crossref
-
Gutiérrez José, Sierra José, Medina Ricardo, Puchi Marcia, Imschenetzky María, van Wijnen Andre, Lian Jane, Stein Gary, Stein Janet, Montecino Martin, Interaction of CBFα/AML/PEBP2α Transcription Factors with Nucleosomes Containing Promoter Sequences Requires Flexibility in the Translational Positioning of the Histone Octamer and Exposure of the CBFα Site, Biochemistry, 39, 44, 2000. Crossref
-
Pozner Amir, Goldenberg Dalia, Negreanu Varda, Le Shu-Yun, Elroy-Stein Orna, Levanon Ditsa, Groner Yoram, Transcription-Coupled Translation Control of AML1/RUNX1 Is Mediated by Cap- and Internal Ribosome Entry Site-Dependent Mechanisms, Molecular and Cellular Biology, 20, 7, 2000. Crossref
-
Marshall Leslie J., Moore Amy C., Ohki Misao, Kitabayashi Issay, Patterson David, Ornelles David A., RUNX1 Permits E4orf6-Directed Nuclear Localization of the Adenovirus E1B-55K Protein and Associates with Centers of Viral DNA and RNA Synthesis, Journal of Virology, 82, 13, 2008. Crossref
-
Davis J Nathan, Williams B Jill, Herron Jeffrey T, Galiano Floyd J, Meyers Shari, ETO-2, a new member of the ETO-family of nuclear proteins, Oncogene, 18, 6, 1999. Crossref
-
Zeng Congmei, McNeil Sandra, Pockwinse Shirwin, Nickerson Jeffrey, Shopland Lindsay, Lawrence Jeanne B., Penman Sheldon, Hiebert Scott, Lian Jane B., van Wijnen André J., Stein Janet L., Stein Gary S., Intranuclear targeting of AML/CBFα regulatory factors to nuclear matrix-associated transcriptional domains, Proceedings of the National Academy of Sciences, 95, 4, 1998. Crossref
-
Westendorf Jennifer J., Yamamoto Cindy M., Lenny Noel, Downing James R., Selsted Michael E., Hiebert Scott W., The t(8;21) Fusion Product, AML-1–ETO, Associates with C/EBP-α, Inhibits C/EBP-α-Dependent Transcription, and Blocks Granulocytic Differentiation, Molecular and Cellular Biology, 18, 1, 1998. Crossref
-
Ning Yang-Min, Robins Diane M., AML3/CBFα1 Is Required for Androgen-specific Activation of the Enhancer of the Mouse Sex-limited Protein (Slp) Gene, Journal of Biological Chemistry, 274, 43, 1999. Crossref
-
Lutterbach Bart, Westendorf Jennifer J., Linggi Bryan, Patten Andrea, Moniwa Mariko, Davie James R., Huynh Khanh D., Bardwell Vivian J., Lavinsky Robert M., Rosenfeld Michael G., Glass Christopher, Seto Edward, Hiebert Scott W., ETO, a Target of t(8;21) in Acute Leukemia, Interacts with the N-CoR and mSin3 Corepressors, Molecular and Cellular Biology, 18, 12, 1998. Crossref
-
Odaka Yoshinobu, Mally Anirudh, Elliott Liza T, Meyers Shari, Nuclear import and subnuclear localization of the proto-oncoprotein ETO (MTG8), Oncogene, 19, 32, 2000. Crossref
-
Lutterbach Bart, Sun Daxi, Schuetz John, Hiebert Scott W., The MYND Motif Is Required for Repression of Basal Transcription from the Multidrug Resistance 1 Promoter by the t(8;21) Fusion Protein, Molecular and Cellular Biology, 18, 6, 1998. Crossref
-
Silva Fernando P G, Morolli Bruno, Storlazzi Clelia T, Anelli Luisa, Wessels Hans, Bezrookove Vladimir, Kluin-Nelemans Hanneke C, Giphart-Gassler Micheline, Identification of RUNX1/AML1 as a classical tumor suppressor gene, Oncogene, 22, 4, 2003. Crossref
-
Mao Shifeng, Frank Richard C., Zhang Jin, Miyazaki Yasushi, Nimer Stephen D., Functional and Physical Interactions between AML1 Proteins and an ETS Protein, MEF: Implications for the Pathogenesis of t(8;21)-Positive Leukemias, Molecular and Cellular Biology, 19, 5, 1999. Crossref
-
McNeil Sandra, Zeng Congmei, Harrington Kimberly S., Hiebert Scott, Lian Jane B., Stein Janet L., van Wijnen André J., Stein Gary S., The t(8;21) chromosomal translocation in acute myelogenous leukemia modifies intranuclear targeting of the AML1/CBFα2 transcription factor, Proceedings of the National Academy of Sciences, 96, 26, 1999. Crossref
-
Vaillant François, Blyth Karen, Terry Anne, Bell Margaret, Cameron Ewan R, Neil James, Stewart Monica, A full-length Cbfa1 gene product perturbs T-cell development and promotes lymphomagenesis in synergy with MYC, Oncogene, 18, 50, 1999. Crossref
-
Stewart M., Terry A., Hu M., O’Hara M., Blyth K., Baxter E., Cameron E., Onions D. E., Neil J. C., Proviral insertions induce the expression of bone-specific isoforms of PEBP2αA (CBFA1): Evidence for a new myc collaborating oncogene , Proceedings of the National Academy of Sciences, 94, 16, 1997. Crossref
-
Frank Richard C, Sun Xiao, Berguido Francisco J, Jakubowiak Andrzej, Nimer Stephen D, The t(8;21) fusion protein, AML1/ETO, transforms NIH3T3 cells and activates AP-1, Oncogene, 18, 9, 1999. Crossref
-
Bertolotti Anne, Melot Thomas, Acker Joël, Vigneron Marc, Delattre Olivier, Tora Laszlo, EWS, but Not EWS-FLI-1, Is Associated with Both TFIID and RNA Polymerase II: Interactions between Two Members of the TET Family, EWS and hTAF II 68, and Subunits of TFIID and RNA Polymerase II Complexes , Molecular and Cellular Biology, 18, 3, 1998. Crossref
-
Levanon Ditsa, Goldstein Robert E., Bernstein Yael, Tang Hua, Goldenberg Dalia, Stifani Stefano, Paroush Ze’ev, Groner Yoram, Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors, Proceedings of the National Academy of Sciences, 95, 20, 1998. Crossref
-
Shi Meng-Jiao, Stavnezer Janet, CBFα3 (AML2) Is Induced by TGF-β1 to Bind and Activate the Mouse Germline Ig α Promoter, The Journal of Immunology, 161, 12, 1998. Crossref