Inscrição na biblioteca: Guest
Portal Digital Begell Biblioteca digital da Begell eBooks Diários Referências e Anais Coleções de pesquisa
Critical Reviews™ in Eukaryotic Gene Expression
Fator do impacto: 1.841 FI de cinco anos: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN Imprimir: 1045-4403
ISSN On-line: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v10.i1.20
12 pages

Understanding "Active" Chromatin: A Historical Perspective of Chromatin Remodeling

Jocelyn E. Krebs
Program in Molecular Medicine and Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 373 Plantation Street, Worcester MA 01605
Craig L. Peterson
Program in Molecular Medicine and Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 373 Plantation Street, Worcester MA 01605

RESUMO

Two phenomena have long been observed to correlate with transcriptionally active chromatin: increased histone acetylation and increased sensitivity to nucleases, including specific patterns of nuclease hypersensitivity in the promoters of active or inducible genes. Work in recent years has at last identified protein complexes required to form these hallmarks of active chromatin: histone acetyltransferases (HATs) and ATP-dependent chromatin remodeling complexes. This review traces the history of these discoveries, including the development of essential tools that allowed the major advances in the field, and describes the current understanding of the interactions between HATs and ATP-dependent remodelers.


Articles with similar content:

Inside the Mammalian Telomere Interactome: Regulation and Regulatory Activities of Telomeres
Critical Reviews™ in Eukaryotic Gene Expression, Vol.16, 2006, issue 2
Dan Liu, Zhou Songyang
Structure-Function Studies of ETS Transcription Factors
Critical Reviews™ in Oncogenesis, Vol.11, 2000, issue 3&4
Murielle Mimeault
Targeting the Insulin-like Growth Factor Receptor: Developing Biomarkers from Gene Expression Profiling
Critical Reviews™ in Oncogenesis, Vol.17, 2012, issue 2
David N. Boone, Adrian V. Lee
The Roles of Bacterial GCN5-Related N-acetyltransferases
Critical Reviews™ in Eukaryotic Gene Expression, Vol.24, 2014, issue 1
Jianping Xie, Jie Zeng, Longxiang Xie, Hongping Luo, Weihua Pan
Architectural Genetic and Epigenetic Control of Regulatory Networks: Compartmentalizing Machinery for Transcription and chromatin remodeling in nuclear Microenvironments
Critical Reviews™ in Eukaryotic Gene Expression, Vol.20, 2010, issue 2
Sayyed Kaleem Zaidi, Janet L. Stein, Jane B. Lian, Martin Montecino, Jeffrey A. Nickerson, Andre J. van Wijnen, Gary S. Stein, Anthony N. Imbalzano