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Critical Reviews™ in Eukaryotic Gene Expression
Fator do impacto: 1.841 FI de cinco anos: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN Imprimir: 1045-4403
ISSN On-line: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukaryotGeneExpr.2013007490
pages 237-255

Pleiotropic Roles of TGFβ/Smad Signaling in the Progression of Chronic Liver Disease

LiHong XU
Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology;the First Affiliated Hospital of Shihezi University
DeAn Tian
Department of Gastroenterology & Hepatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology ,WuHan 430074, China
Yong Zheng
Department of Digestology, the First Affiliated Hospital of Shihezi University, Xinjiang 832008, China

RESUMO

A wide range of pathophysiological changes are involved in the progression of chronic liver disease (CLD). The multifunctional cytokine transforming growth factor β (TGFβ) can cross talk with other signaling pathways and mediate nearly every aspect of cell physiology from growth to differentiation and cell death. TGFβ can maintain immune response homeostasis and mediate wound-healing responses. Additionally, not only can TGFβ prevent the occurrence of hepatocarcinoma by regulating the proliferation of hepatic progenitor cells, TGFβ can also play important roles in blunting inflammation by interfering with tumor inhibition response generated by inflammatory mediators. The TGFβ/Smad signaling pathway is an important response that is mediated by TGFβ. This pathway also plays multiple functions in the progression of chronic liver disease. The pleiotropic effects of TGFβ and TGFβ/Smad signaling create challenges in the treatment of CLD under conditions that might interfere with the TGFβ signaling pathway. Detailed understanding of the pleiotropic roles of TGFβ signaling in CLD might assist in the selection of more accurate therapeutic approaches, and in the targeting of the right type of cell in the development of treatment strategies, and ultimately in achieving the desired therapeutic effects.


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