Publicou 6 edições por ano
ISSN Imprimir: 1045-4403
ISSN On-line: 2162-6502
Indexed in
Tumor Suppressor Maspin as a Rheostat in HDAC Regulation to Achieve the Fine-Tuning of Epithelial Homeostasis
RESUMO
Maspin, a class II tumor suppressor, is often downregulated during tumor progression and its depletion from the nucleus is associated with poor prognosis. Recently, we reported that reintroduction of maspin is sufficient for redifferentiation of prostate cancer cells to epithelial phenotype, a reversal of epithelial-to-mesenchymal transition. We have linked this effect of maspin with its ability to directly inhibit HDAC1, thereby influencing the acetylation state of transcription factors and other proteins. Maspin overexpression leads to changes in the expression level of a large number of proteins and these changes are often microenvironment specific. In this review, we summarize the epigenetic effects of maspin and provide comprehensive bioinformatic analysis of microarray-derived gene expression changes caused by maspin in different microenvironments. The analysis was performed on multiple levels, including identification of statistically enriched gene ontology groups, detection of overreprepresented transcription factors binding sites in promoters of differentially expressed genes, followed by searching for key nodes of regulatory networks controlling these transcription factors. The results are consistent with our hypothesis that maspin serves as an endogenous regulator of HDAC activity and suggest that the effect of maspin is primarily mediated by TGFβ, β-catenin/E-cadherin pathways, and network key nodes such as Abl kinase, p62, IL1, and caspases 6 and 8.
-
Chu Gina Chia-Yi, Chung Leland W. K., RANK-mediated signaling network and cancer metastasis, Cancer and Metastasis Reviews, 33, 2-3, 2014. Crossref
-
Dzinic Sijana H., Kaplun Alexander, Li Xiaohua, Bernardo Margarida, Meng Yonghong, Dean Ivory, Krass David, Stemmer Paul, Shin Namhee, Lonardo Fulvio, Sheng Shijie, Koul Hari K., Identification of an Intrinsic Determinant Critical for Maspin Subcellular Localization and Function, PLoS ONE, 8, 11, 2013. Crossref
-
XU LIANG, LIU HONGYUAN, YU JU, WANG ZHONGYONG, ZHU QING, LI ZONGPING, ZHONG QI, ZHANG SHUYU, QU MINGQI, LAN QING, Methylation-induced silencing of maspin contributes to the proliferation of human glioma cells, Oncology Reports, 36, 1, 2016. Crossref
-
Sheng Shijie, Margarida Bernardo M., Dzinic Sijana H., Chen Kang, Heath Elisabeth I., Sakr Wael A., Tackling tumor heterogeneity and phenotypic plasticity in cancer precision medicine: our experience and a literature review, Cancer and Metastasis Reviews, 37, 4, 2018. Crossref
-
Sun Pengming, Wu Qibin, Ruan Guanyu, Zheng Xiu, Song Yiyi, Zhun Jianfan, Wu Lixiang, Gotlieb Walter H., Expression patterns of maspin and mutant p53 are associated with the development of gestational trophoblastic neoplasia, Oncology Letters, 12, 5, 2016. Crossref
-
Dzinic Sijana H., Mahdi Zaid, Bernardo M. Margarida, Vranic Semir, Beydoun Haya, Nahra Nadine, Alijagic Amra, Harajli Deanna, Pang Aaron, Saliganan Dan M., Rahman Abid M., Skenderi Faruk, Hasanbegovic Berisa, Dyson Gregory, Beydoun Rafic, Sheng Shijie, Nie Daotai, Maspin differential expression patterns as a potential marker for targeted screening of esophageal adenocarcinoma/gastroesophageal junction adenocarcinoma, PLOS ONE, 14, 4, 2019. Crossref
-
Lin Yu-Hsiang, Tsui Ke-Hung, Chang Kang-Shuo, Hou Chen-Pang, Feng Tsui-Hsia, Juang Horng-Heng, Maspin is a PTEN-Upregulated and p53-Upregulated Tumor Suppressor Gene and Acts as an HDAC1 Inhibitor in Human Bladder Cancer, Cancers, 12, 1, 2019. Crossref
-
Shi Heidi Y., Zhang Jeremy S., Zhang Ming, Maspin Is a Multifunctional Tumor-Suppressing Serpin, in The Serpin Family, 2015. Crossref
-
Dzinic Sijana H., Chen Kang, Thakur Archana, Kaplun Alexander, Daniel Bonfil R., Li Xiaohua, Liu Jason, Margarida Bernardo M., Saliganan Allen, Back Jessica B., Yano Hiroshi, Schalk Dana L., Tomaszewski Elyse N., Beydoun Ahmed S., Dyson Gregory, Mujagic Adelina, Krass David, Dean Ivory, Mi Qing-Sheng, Heath Elisabeth, Sakr Wael, Lum Lawrence G., Sheng Shijie, Maspin expression in prostate tumor elicits host anti-tumor immunity, Oncotarget, 5, 22, 2014. Crossref
-
Dean Ivory, Dzinic Sijana H., Bernardo M. Margarida, Zou Yi, Kimler Vickie, Li Xiaohua, Kaplun Alexander, Granneman James, Mao Guangzhao, Sheng Shijie, The secretion and biological function of tumor suppressor maspin as an exosome cargo protein, Oncotarget, 8, 5, 2017. Crossref
-
Sheng Shijie, Bernardo Margarida, Dzinic Sijana H., Chen Kang, Sakr Wael A., The vulnerable primed cancer stem cells in disguise: demystifying the role of Maspin, Cancer and Metastasis Reviews, 41, 4, 2022. Crossref
-
Tang Sijie, Ling Zhongli, Jiang Jiajia, Gu Xiang, Leng Yuzhong, Wei Chaohui, Cheng Huiying, Li Xiaohua, Integrating the tumor-suppressive activity of Maspin with p53 in retuning the epithelial homeostasis: A working hypothesis and applicable prospects, Frontiers in Oncology, 12, 2022. Crossref