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Critical Reviews™ in Eukaryotic Gene Expression

Publicou 6 edições por ano

ISSN Imprimir: 1045-4403

ISSN On-line: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

Indexed in

Edible Vaccine: A New Platform for the Development of Malaria Vaccine

Volume 22, Edição 3, 2012, pp. 243-248
DOI: 10.1615/CritRevEukarGeneExpr.v22.i3.70
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RESUMO

The plasmodium vivax is the most prevalent malaria parasite. The world essentially needs a malaria vaccine to alleviate the human suffering associated with the parasitic disease that kills more than one million people annually. The use of plants for the expression of the proteins of disease-causing vehicle in transgenic plants has been increasingly used in the development of experimental vaccines, largely oriented to the improvement of edible vaccines. Currently, through modern biotechnology, there has been a revival in obtaining a new edible vaccine against the malaria parasite from plant sources. Through genetic alteration, it is now recognized that plants are potentially a new source of recombinant proteins including vaccines, antibodies, blood substitutes, and other therapeutic entities. Plant-derived antibodies and other proteins are mostly valuable since they are free of mammalian viral vectors and human pathogens. Although significant progress has been achieved in the research for edible vaccine in Plasmodium falciparum, limited progress has been made in the Plasmodium vivax component that might be eligible for edible vaccine development. We describe the overall strategy recommended by plants, which include high biomass production and low cost of cultivation, relatively fast "gene to protein" time, low capital and operating costs, outstanding scalability, eukaryotic posttranslational modifications, and a relatively high protein yield.

CITADO POR
  1. Gregory James A., Mayfield Stephen P., Developing inexpensive malaria vaccines from plants and algae, Applied Microbiology and Biotechnology, 98, 5, 2014. Crossref

  2. Mangan Mary E., Production of Medicines from Engineered Proteins in Plants: Proteins for a New Century, in Plant Biotechnology, 2014. Crossref

  3. Khan Faria, Szmigielski Rafal, Gul Alvina, Altay Volkan, Ozturk Munir, Advancements in plant transgenomics approach for the biopharmaceutics and vaccines production, in Biodiversity and Biomedicine, 2020. Crossref

  4. Sahoo Ankit, Mandal Ashok Kumar, Dwivedi Khusbu, Kumar Vikas, A cross talk between the immunization and edible vaccine: Current challenges and future prospects, Life Sciences, 261, 2020. Crossref

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