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Critical Reviews™ in Eukaryotic Gene Expression
Fator do impacto: 1.841 FI de cinco anos: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN Imprimir: 1045-4403
ISSN On-line: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukaryotGeneExpr.v14.i12.50
10 pages

Chromatin Domains and Territories: Flexibly Rigid

Sergey V. Razin
Laboratory of Structural and Functional Organization of hromosomes, Institute of Gene Biology of the Russian Academy of Sciences, Vavilov Str. 34/5, 117334 Moscow, Russia
Andrei Petrov
Department of Chemistry, Moscow State University; and CNRS UMR-8126, Institut Gustave Roussy, Villejuif 94805, France
Alan Hair
CNRS UMR-8126, Institut Gustave Roussy, Villejuif 94805, France
Yegor S. Vassetzky
CNRS UMR-8126, Institut Gustave Roussy, Villejuif 94805, France

RESUMO

The nucleus is a highly organized solid-state system, rigid and flexible at the same time, where enzymes are organized in complex processing factories. This is achieved by the organization of nuclear DNA into territories and domains, which allow compartmentalization and compaction without sacrificing accessibility. The present review discusses the implications of the organization of chromosomal domains and territories in development and carcinogenesis.


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