Publicou 6 edições por ano
ISSN Imprimir: 1045-4403
ISSN On-line: 2162-6502
Indexed in
Association of ERCC1 and ERCC2 Gene Polymorphisms with Pancreatic Cancer Risk: A Meta-Analysis
RESUMO
In this meta-analysis, all relative literature was retrieved through the Embase and PubMed databases. Moreover, the Stata 12.0 software package was applied to calculate the pooled odds ratio (OR) of the 95% confidence interval (CI). A total of seven studies was identified to analyze the relation between ERCC1 and ERCC2 gene polymorphisms and pancreatic cancer risk. The results showed that ERCC2 rs13181 polymorphism was associated with pancreatic cancer (CC vs. AA: OR = 1.53, 95% CI = 1.24-1.90; AC vs. AA: OR = 1.06, 95% CI = 0.92-1.22; dominant model: OR = 1.16, 95% CI = 1.02-1.32; recessive model: OR = 1.39, 95% CI = 0.13-1.70). For ERCC1 rs3212986 polymorphism, a significant correlation with pancreatic cancer risk was found (TT vs. GG: OR = 2.33, 95% CI = 1.73-3.14; GT vs. GG: OR = 1.34, 95% CI = 1.11-1.63; dominant model: OR = 1.50, 95% CI = 1.25-1.80; recessive model: OR = 1.98, 95% CI = 1.50-2.62). A lack of association was found for ERCC1 rs11615 polymorphism (TT vs. CC: OR = 1.21, 95% CI = 0.93-1.56; CT vs. CC: OR = 1.02, 95% CI = 0.87-1.21; dominant model: OR = 1.43, 95% CI = 0.80-2.50; recessive model: OR = 0.99, 95% CI = 0.65-1.51).
-
Siegel RL, Miller KD, Jemal A. Cancer statistics, 2015. CA Cancer J Clin. 2015;65:5-29.
-
Gillen S, Schuster T, Meyer Zum Buschenfelde C, Friess H, Kleeff J. Preoperative/neoadjuvant therapy in pancreatic cancer: A systematic review and meta-analysis of response and resection percentages. PLoS Med. 2010;7:e1000267.
-
Kim VM, Ahuja N. Early detection of pancreatic cancer. Chin J Cancer Res. 2015;27:321-31.
-
Zheng Z, Zheng R, He Y, Sun X, Wang N, Chen T, Chen W. Risk factors for pancreatic cancer in China: A multi-center case-control study. J Epidemiol. 2016;26:64-70.
-
Ginsberg G, Angle K, Guyton K, Sonawane B. Polymorphism in the DNA repair enzyme XRCC1: Utility of current database and implications for human health risk assessment. Mutat Res Fundam Mol Mech Mutagen. 2011;727:1-15.
-
Wood RD, Mitchell M, Sgouros J, Lindahl T. Human DNA repair genes. Science. 2001;291:1284-9.
-
Kiyohara C, Yoshimasu K. Genetic polymorphisms in the nucleotide excision repair pathway and lung cancer risk: A meta-analysis. Int J Med Sci. 2007;4:59-71.
-
Wu R, Li B. A multiplicative-epistatic model for analyzing interspecific differences in outcrossing species. Biometrics. 1999;55:355-65.
-
Lu YM, Cao LF, Li YQ, Li C. RANTES gene polymorphisms and risk of pediatric asthma: A meta-analysis. Exp Ther Med. 2012;4:918-22.
-
Lee YH, Choi SJ, Ji JD, Song GG. Associations between the angiotensin-converting enzyme insertion/ deletion polymorphism and susceptibility to vasculitis: A meta-analysis. J Renin Angiotensin Aldosterone Syst. 2012;13:196-201.
-
Tobias A. Assessing the influence of a single study in the meta-analysis estimate. Stata Tech Bull. 1999;8:15-7.
-
Jiao L, Hassan MM, Bondy ML, Abbruzzese JL, Evans DB, Li D. The XPD Asp312Asn and Lys751Gln polymorphisms, corresponding haplotype, and pancreatic cancer risk. Cancer Lett. 2007;245:61-8.
-
McWilliams RR, Bamlet WR, Cunningham JM, Goode EL, de Andrade M, Boardman LA, Petersen GM. Polymorphisms in DNA repair genes, smoking, and pancreatic adenocarcinoma risk. Cancer Res. 2008;68:4928-35.
-
Hocevar BA, Kamendulis LM, Pu X, Perkins SM, Wang ZY, Johnston EL, DeWitt JM, Li L, Loehrer PJ, Klaunig JE, Chiorean EG. Contribution of environment and genetics to pancreatic cancer susceptibility. PLoS One. 2014;9:e90052.
-
Zhao F, Shang Y, Zeng C, Gao D, Li K. Association of single nucleotide polymorphisms of DNA repair genes in NER pathway and susceptibility to pancreatic cancer. Int J Clin Exp Pathol. 2015;8:11579-86.
-
Ying MF, Zhao R. Role of single nucleotide polymorphisms of DNA repair genes in susceptibility to pancreatic cancer in Chinese population. Genet Mol Res. 2016;15(1).
-
Sileng A, Pan R, Li G, Wang W, Li J, Zhang M, Li M, Zhang Z, Lin J, Liao C. ERCC1 rs3212986 and ERCC2 rs13181 gene polymorphisms contributes to the susceptibility to pancreatic cancer in a Chinese population. Int J Clin Exp Pathol. 2016;9:5686-93.
-
He MG, Zheng K, Tan D, Wang ZX. Association between ERCC1 and ERCC2 gene polymorphisms and susceptibility to pancreatic cancer. Genet Mol Res. 2016;15.
-
Feng YZ, Liu YL, He XF, Wei W, Shen XL, Xie DL. Association between the XRCC1 Arg194Trp polymorphism and risk of cancer: Evidence from 201 case-control studies. Tumour Biol. 2014;35:10677-97.
-
Li J, Li Z, Feng L, Guo W, Zhang S. Polymorphisms of DNA repair gene XRCC1 and hepatocellular carcinoma risk among East Asians: A meta-analysis. Tumour Biol. 2013;34:261-9.
-
Dai L, Duan F, Wang P, Song C, Wang K, Zhang J. XRCC1 gene polymorphisms and lung cancer susceptibility: A metaanalysis of 44 case-control studies. Mol Biol Rep. 2012;39:9535-47.