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Critical Reviews™ in Eukaryotic Gene Expression
Fator do impacto: 1.841 FI de cinco anos: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN Imprimir: 1045-4403
ISSN On-line: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v19.i1.40
pages 73-88

Molecular Mechanisms in Coupling of Bone Formation to Resorption

T. John Martin
St. Vincent's Institute of Medical Research and University of Melbourne Department of Medicine, Fitzroy, 3065, Victoria, Australia
Jonathan H. Gooi
St. Vincent's Institute of Medical Research and University of Melbourne Department of Medicine, Fitzroy, 3065, Victoria, Australia
Natalie A. Sims
St. Vincent's Institute of Medical Research and University of Melbourne Department of Medicine, Fitzroy, 3065, Victoria, Australia

RESUMO

Bone remodeling is the process of removal and replacement of bone, taking place at many sites throughout the skeleton and regulated mainly by locally generated factors. Its purposes are to repair damaged bone, remove old bone, and facilitate skeletal responses to changes in loading requirements. Cells of the osteoblast lineage control the formation and activity of osteoclasts, which are responsible for initiation and execution of resorption at remodeling sites. The bone resorbed by osteoclasts is replaced through the differentiation and activity of osteoblasts. The consequent formation must match closely the amount of bone that is resorbed at each site. This coupling of the two processes is essential for bone balance. Both resorption products and osteoclast-derived factors contribute to the coupling of bone formation to resorption in bone remodeling. This review considers the molecular mechanisms and intercellular communication processes involved in remodeling and coupling.