Inscrição na biblioteca: Guest
Portal Digital Begell Biblioteca digital da Begell eBooks Diários Referências e Anais Coleções de pesquisa
Critical Reviews™ in Eukaryotic Gene Expression
Fator do impacto: 2.156 FI de cinco anos: 2.255 SJR: 0.649 SNIP: 0.599 CiteScore™: 3

ISSN Imprimir: 1045-4403
ISSN On-line: 2162-6502

Volume 30, 2020 Volume 29, 2019 Volume 28, 2018 Volume 27, 2017 Volume 26, 2016 Volume 25, 2015 Volume 24, 2014 Volume 23, 2013 Volume 22, 2012 Volume 21, 2011 Volume 20, 2010 Volume 19, 2009 Volume 18, 2008 Volume 17, 2007 Volume 16, 2006 Volume 15, 2005 Volume 14, 2004 Volume 13, 2003 Volume 12, 2002 Volume 11, 2001 Volume 10, 2000 Volume 9, 1999 Volume 8, 1998 Volume 7, 1997 Volume 6, 1996 Volume 5, 1995 Volume 4, 1994

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukaryotGeneExpr.2015013022
pages 77-89

Emerging Roles of CCCH-Type Zinc Finger Proteins in Destabilizing mRNA Encoding Inflammatory Factors and Regulating Immune Responses

Chuanbin Yang
School of Chinese Medicine, The University of Hong Kong, Hong Kong, China
Shaofei Huang
Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China
Xuanbin Wang
Laboratory of Chinese Herbal Pharmacology, Renmin Hospital, Hubei University of Medicine, Shiyan, China
Yong Gu
Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China; Laboratory of Chinese Herbal Pharmacology, Renmin Hospital, Hubei University of Medicine, Shiyan, China


Posttranscriptional gene regulation is a rapid and effective way to mediate the expression of inflammatory genes. CCCH-type zinc finger proteins are nucleotide-binding molecules involved in RNA metabolism pathways such as RNA splicing, polyadenylation, and messenger RNA (mRNA) decay. Among these proteins, tristetraproline, Roquins, and Regnase-1/monocyte chemotactic protein-1-induced protein-1 have been recently reported to be responsible for mRNA instability. They bind to mRNAs harboring unique motifs and induce mRNA decay. In this review we summarize current progress regarding the specific characteristics of sequences and structures in the 3' untranslated regions of mRNAs that are recognized by tristetraproline, Roquins, and Regnase-1. The target mRNAs to be destabilized by those CCCH-type zinc finger proteins also are included. Notably, most target mRNAs encode cytokines and other inflammatory mediators, suggesting the immune regulation role of CCCH zinc finger proteins. Mice carrying a genetic null allele or modification of these genes display severe symptoms of autoimmune diseases. Taken together, data show that CCCH-type zinc finger proteins play a crucial role in regulating immune response by targeting multiple mRNAs, and including decay. Further understanding the functions of these proteins may provide new therapeutic targets for immune-related disorders in the future.

Articles with similar content:

Expression and Function of Recombination Activating Genes in Mature В Cells
Critical Reviews™ in Immunology, Vol.18, 1998, issue 3
Masaki Hikida, Hitoshi Ohmori
Structural Aspects of Signal Transduction in B-Cells
Critical Reviews™ in Immunology, Vol.16, 1996, issue 3
Mauno Vihinen, C. I. Edward Smith
Cell Adhesion Molecules: Selectins and Integrins
Critical Reviews™ in Immunology, Vol.19, 1999, issue 5-6
Francisco Sanchez-Madrid, Roberto González-Amaro
Regulation of aicda Expression and AID Activity: Relevance to Somatic Hypermutation and Class Switch DNA Recombination
Critical Reviews™ in Immunology, Vol.27, 2007, issue 4
Ahmed Al-Qahtani, Seok-Rae Park, Egest J. Pone, Paolo Casali, Hong Zan, Zhenming Xu
The Role of Transcription Factor YY1 in the Biology of Cancer
Critical Reviews™ in Oncogenesis, Vol.22, 2017, issue 1-2
Neeraj Agarwal, Dan Theodorescu