Publicou 6 edições por ano
ISSN Imprimir: 1045-4403
ISSN On-line: 2162-6502
Indexed in
TGF-β in Inflammatory Bowel Diseases: A Tale of the Janus-Like Cytokine
RESUMO
Transforming growth factor-β (TGF-β) is a pleiotropic cytokine that controls an immense number of cellular responses and plays a prominent role in maintaining homeostasis of most human organs. In the intestine, the TGF-β is involved in mucosal defense, immune tolerance, inhibition of acute inflammation, promoting the wound-healing process, and suppressing tumor initiation. However, TGF-β exhibits Janus-like features under certain physiologic conditions and chronic inflammation (e.g., inflammatory bowel diseases [IBDs]). Excessive TGF-β in IBDs favors chronic inflammation, incurs pathologic remolding, and facilitates the progression of colitis-associated inflammation (CAC). Considering the increasingly crucial roles of TGF-Β in the development of IBDs, we overview its pathways and multifaceted effects at the steady-state and IBD conditions of the gut, respectively. In addition, we present potential therapeutic strategies aimed at restoring normal TGF-β signaling in IBDs.
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Chen Weigang, Pu Aimin, Sheng Baifa, Zhang Zhicao, Li Liangzi, Liu Zhongze, Wang Qimeng, Li Xiang, Ma Yuanhang, Yu Min, Sun Lihua, Qiu Yuan, Yang Hua, Aryl hydrocarbon receptor activation modulates CD8αα+TCRαβ+ IELs and suppression of colitis manifestations in mice, Biomedicine & Pharmacotherapy, 87, 2017. Crossref
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Guo Xiutian, Li Mao-Gang, Li Shan-Shan, Liu Feng-Hua, Liu Zhan-Ju, Yang Ping-Chang, Tumor necrosis factor suppresses interleukin 10 in peripheral B cells via upregulating Bcl2-like protein 12 in patients with inflammatory bowel disease, Cell Biochemistry and Function, 35, 2, 2017. Crossref
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Cao Linghui, Huang Feiyu, Massey Isaac Yaw, Wen Cong, Zheng Shuilin, Xu Shuaishuai, Yang Fei, Effects of Microcystin-LR on the Microstructure and Inflammation-Related Factors of Jejunum in Mice, Toxins, 11, 9, 2019. Crossref
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Lv Lin, Yao Yucai, Zhao Gang, Zhu Guiyue, Rutin inhibits coronary heart disease through ERK1/2 and Akt signaling in a porcine model, Experimental and Therapeutic Medicine, 2017. Crossref
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Filidou Eirini, Kolios George, Probiotics in Intestinal Mucosal Healing: A New Therapy or an Old Friend?, Pharmaceuticals, 14, 11, 2021. Crossref
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Sommer Katrin, Wiendl Maximilian, Müller Tanja M., Heidbreder Karin, Voskens Caroline, Neurath Markus F., Zundler Sebastian, Intestinal Mucosal Wound Healing and Barrier Integrity in IBD–Crosstalk and Trafficking of Cellular Players, Frontiers in Medicine, 8, 2021. Crossref
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Chen Huey‐Miin, MacDonald Justin A., Death‐associated protein kinases and intestinal epithelial homeostasis, The Anatomical Record, 2022. Crossref
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Montoya Jose G., Holmes Tyson H., Anderson Jill N., Maecker Holden T., Rosenberg-Hasson Yael, Valencia Ian J., Chu Lily, Younger Jarred W., Tato Cristina M., Davis Mark M., Cytokine signature associated with disease severity in chronic fatigue syndrome patients, Proceedings of the National Academy of Sciences, 114, 34, 2017. Crossref