Inscrição na biblioteca: Guest
Portal Digital Begell Biblioteca digital da Begell eBooks Diários Referências e Anais Coleções de pesquisa
Critical Reviews™ in Eukaryotic Gene Expression
Fator do impacto: 1.841 FI de cinco anos: 1.927 SJR: 0.627 SNIP: 0.516 CiteScore™: 1.96

ISSN Imprimir: 1045-4403
ISSN On-line: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v17.i4.40
pages 295-316

Epigenetic Control of Tumor Suppression

Stela S. Palii
Department of Biochemistry and Molecular Biology, Shands Cancer Center, University of Florida, P.O. Box 100245, Gainesville, FL 32610
Keith D. Robertson
Department of Biochemistry and Molecular Biology, Shands Cancer Center, University of Florida, P.O. Box 100245, Gainesville, FL 32610

RESUMO

Epigenetic silencing of tumor suppressor genes is a major contributor to neoplastic transformation and is an area of intense research. Identification of genes that undergo cancer-specific CpG island hypermethylation in combination with repressive histone tail modifications (deacetylation and methylation) and correlation of these data with tumor stage, progression, and long-term prognosis are becoming increasingly common. The efforts directed toward elucidating the mechanisms of neoplastic tumor suppression catalyzed the convergence of epigenetics, chromatin remodeling, and pharmacology of epigenome-altering drugs. This review discusses the key findings and current concepts concerning the epigenetic control of tumor suppression and analyzes the role of DNA hypermethylation in conjunction with histone deacetylation and methylation profiles of tumor suppressor genes as it relates to epigenetic loss of function in malignancy. Examples arguing for hierarchic control and interdependent regulation within the cellular tumor suppression networks are also presented. Finally, the necessity of a human epigenome database integrating the continually produced experimental information for use by both researchers and clinicians for prospective translational multidisciplinary studies of tumor suppressor networks is rationalized.


Articles with similar content:

Regulating RNA Binding Motif 5 Gene Expression− A Novel Therapeutic Target for Lung Cancer
Journal of Environmental Pathology, Toxicology and Oncology, Vol.36, 2017, issue 2
Niranjali Devaraj, Venugopal Vinod Prabhu
Functional Implications of BRCA1 for Early Detection, Prevention, and Treatment of Breast Cancer
Critical Reviews™ in Eukaryotic Gene Expression, Vol.16, 2006, issue 3
Alvaro N. A. Monteiro, Virna Dapic
Epigenetic Modification Related to Acetylation of Histone and Methylation of DNA as a Key Player in Immunological Disorders
Critical Reviews™ in Eukaryotic Gene Expression, Vol.29, 2019, issue 1
Muhammad Imran Qadir, Farha Anwer
Genetic and Epigenetic Control of RKIP Transcription
Critical Reviews™ in Oncogenesis, Vol.19, 2014, issue 6
Milad S. Bitar, Kevin Qin, Kam C. Yeung, Fahd Al-Mulla, Hanna Tegegne, Ila Datar, Robert J. Trumbly
Tumor Protein D52 Overexpression and Gene Amplification in Cancers from a Mosaic of Microarrays
Critical Reviews™ in Oncogenesis, Vol.14, 2008, issue 1
Jayne R. Hardy, Jennifer A. Byrne, Judith Weidenhofer, Keerthi Thamotharampillai, Mona Shehata