Inscrição na biblioteca: Guest
Portal Digital Begell Biblioteca digital da Begell eBooks Diários Referências e Anais Coleções de pesquisa
Critical Reviews™ in Eukaryotic Gene Expression
Fator do impacto: 1.841 FI de cinco anos: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN Imprimir: 1045-4403
ISSN On-line: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v20.i3.20
pages 195-212

Sclerosing Bone Disorders: Too Much of a Good Thing

Bram Perdu
Department of Medical Genetics, University and University Hospital Antwerp
Wim Van Hul
Department of Medical Genetics, University of Antwerp (UA) and Department of Medical Genetics, University Hospital of Antwerp (UZA)

RESUMO

Osteoporosis is, because of its high prevalence and morbidity, a major health problem in our aging population. Epidemiological studies clearly indicated a heritability of up to 80% for relevant bone parameters with an additional role for environmental factors, such as food intake and physical exercise. A major contribution to our current understanding of bone homeostasis is obtained by studying monogenic diseases with an increased bone density, the sclerosing bone dysplasias. Gene identifications have revealed relevant pathways and mechanisms both in the bone-resorbing osteoclasts and bone-forming osteoblasts. Furthermore, natural variants within these genes turned out to have an influence on bone mineral density in the general population. Finally, interesting drug targets for the prevention and treatment of osteoporosis were revealed. Although many major breakthroughs have been realized, still a huge amount of significant information is hidden in these pathologies as the function of many of these genes and newly identified pathways is not, or only partially, clear.


Articles with similar content:

The Role of Cytokines and Growth Factors as Mediators of the Effects of Systemic Hormones at the Bone Local Level
Critical Reviews™ in Eukaryotic Gene Expression, Vol.5, 1995, issue 3-4
Gregory R. Mundy, Jose A. Riancho
Sirtuins in Brain Aging and Neurological Disorders
Critical Reviews™ in Eukaryotic Gene Expression, Vol.27, 2017, issue 4
Muhammad Imran Qadir, Sidra Anwar
Human Defensins and Cathelicidins in the Skin: Beyond Direct Antimicrobial Properties
Critical Reviews™ in Immunology, Vol.26, 2006, issue 6
Hideoki Ogawa, Isao Nagaoka, Francois Niyonsaba
Monogenic and Complex Forms of Obesity: Insights from Genetics Reveal the Leptin-Melanocortin Signaling Pathway as a Common Player
Critical Reviews™ in Eukaryotic Gene Expression, Vol.22, 2012, issue 4
Sigri Beckers, Doreen Zegers, Luc F. Van Gaal, Wim Van Hul
The Role of Zinc in Life: A Review
Journal of Environmental Pathology, Toxicology and Oncology, Vol.25, 2006, issue 3
Leonardo Caltavuturo, Stefania Frassinetti, Marco Cini, Giorgio L. Bronzetti, Clara Della Croce