Publicou 6 edições por ano
ISSN Imprimir: 1045-4403
ISSN On-line: 2162-6502
Indexed in
Antibacterial Activity of Novel Strains of Bacteriophages: An Experimental Approach
RESUMO
The evolution of antibiotic resistance in bacteria has increased research in the development of alternative therapies to conventional drugs. In this study, isolated phages were characterized and antibacterial activity was determined by standard agar disc diffusion method. The phages showed maximum propagation at 37°C to 40°C and highest viability at pH 7. Sugars influenced the bacteriophage viability. Sodium chloride decreased the phage propagation. Calcium chloride and magnesium chloride increased the phage propagation up to a certain limit. SDS-PAGE analysis confirmed the presence of protein cover and showed the various bands ranging from 10 to 200 kDa. Nucleic acid analysis confirmed the presence of RNA with a size of approximately 20 kb. Transmission electron microscopy indicated that the phages belong to Siphoviridae, Leviviridae, and Podoviridae families.
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Li Jian, Zhao Feng, Zhan Wenyao, Li Zhiqi, Zou Liang, Zhao Qi, Challenges for the application of bacteriophages as effective antibacterial agents in the food industry, Journal of the Science of Food and Agriculture, 102, 2, 2022. Crossref
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Adeniji Oluwaseun Ola, Nontongana Nolonwabo, Okoh Janet Chiyem, Okoh Anthony Ifeanyi, The Potential of Antibiotics and Nanomaterial Combinations as Therapeutic Strategies in the Management of Multidrug-Resistant Infections: A Review, International Journal of Molecular Sciences, 23, 23, 2022. Crossref