Publicou 6 edições por ano
ISSN Imprimir: 1045-4403
ISSN On-line: 2162-6502
Indexed in
Increased Dosage of the RUNX1/AML1 Gene: A Third Mode of RUNX Leukemia?
RESUMO
RUNX1/AML1, located on chromosome 21, is a key factor in the generation and maintenance of hematopoietic stem cells and the gene most frequently implicated in human leukemias. Chromosome translocations and point mutations are well-documented genetic alterations in RUNX leukemia (also known as CBF leukemia). In addition, overdosage or overexpression of RUNX1 is suspected to be a third mode of RUNX1 involvement in leukemogenesis. The possibility that this mode might underlie Down syndrome-related leukemias caused by trisomy of chromosome 21 is discussed.
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Dierssen Mara, Down syndrome: the brain in trisomic mode, Nature Reviews Neuroscience, 13, 12, 2012. Crossref
-
Kuo Ya-Huei, Zaidi Sayyed K., Gornostaeva Svetlana, Komori Toshihisa, Stein Gary S., Castilla Lucio H., Runx2 induces acute myeloid leukemia in cooperation with Cbfβ-SMMHC in mice, Blood, 113, 14, 2009. Crossref
-
Vacano Guido N., Duval Nathan, Patterson David, The Use of Mouse Models for Understanding the Biology of Down Syndrome and Aging, Current Gerontology and Geriatrics Research, 2012, 2012. Crossref
-
Pratap J., Lian J. B., Javed A., Barnes G. L., van Wijnen A. J., Stein J. L., Stein G. S., Regulatory roles of Runx2 in metastatic tumor and cancer cell interactions with bone, Cancer and Metastasis Reviews, 25, 4, 2006. Crossref
-
Kim Jang-Hyun, Choi Joong-Kook, Cinghu Senthilkumar, Jang Ju-Won, Lee You-Soub, Li Ying-Hui, Goh Yun-Mi, Chi Xin-Zi, Lee Kyeong-Sook, Wee Heejun, Bae Suk-Chul, Jab1/CSN5 induces the cytoplasmic localization and degradation of RUNX3, Journal of Cellular Biochemistry, 107, 3, 2009. Crossref
-
Ito Yoshiaki, Bae Suk-Chul, Chuang Linda Shyue Huey, The RUNX family: developmental regulators in cancer, Nature Reviews Cancer, 15, 2, 2015. Crossref
-
Satgé Daniel, Bénard Jean, Carcinogenesis in Down syndrome: What can be learned from trisomy 21?, Seminars in Cancer Biology, 18, 5, 2008. Crossref
-
Xu Xin, Ren Xiuyu, Wang Haiying, Zhao Yao, Yi Zhengjun, Wang Kaifeng, Zhang Shizhuang, Wang Lin, Samuelson David J., Hu Zhenbo, Identification and functional analysis of acute myeloid leukemia susceptibility associated single nucleotide polymorphisms at non-protein coding regions ofRUNX1, Leukemia & Lymphoma, 57, 6, 2016. Crossref
-
Seif Alix E., Pediatric leukemia predisposition syndromes: clues to understanding leukemogenesis, Cancer Genetics, 204, 5, 2011. Crossref
-
Letourneau Audrey, Antonarakis Stylianos E., Genomic determinants in the phenotypic variability of Down syndrome, in Down Syndrome: From Understanding the Neurobiology to Therapy, 197, 2012. Crossref
-
Asou Norio, Yanagida Masatoshi, Huang Liqun, Yamamoto Masayuki, Shigesada Katsuya, Mitsuya Hiroaki, Ito Yoshiaki, Osato Motomi, Concurrent transcriptional deregulation of AML1/RUNX1 and GATA factors by the AML1-TRPS1 chimeric gene in t(8;21)(q24;q22) acute myeloid leukemia, Blood, 109, 9, 2007. Crossref
-
Nah Giselle Sek Suan, Lim Zhi Wei, Tay Boon-Hui, Osato Motomi, Venkatesh Byrappa, van Wijnen Andre, Runx Family Genes in a Cartilaginous Fish, the Elephant Shark (Callorhinchus milii), PLoS ONE, 9, 4, 2014. Crossref
-
Voon Dominic Chih-Cheng, Thiery Jean Paul, The Emerging Roles of RUNX Transcription Factors in Epithelial-Mesenchymal Transition, in RUNX Proteins in Development and Cancer, 962, 2017. Crossref
-
Adamaki Maria, Vlahopoulos Spiros, Lambrou George I, Papavassiliou Athanasios G, Moschovi Maria, Aberrant AML1 gene expression in the diagnosis of childhood leukemias not characterized by AML1-involved cytogenetic abnormalities, Tumor Biology, 39, 3, 2017. Crossref
-
Nah Giselle Sek Suan, Tay Boon-Hui, Brenner Sydney, Osato Motomi, Venkatesh Byrappa, Nikolaidis Nikolas, Characterization of the Runx Gene Family in a Jawless Vertebrate, the Japanese Lamprey (Lethenteron japonicum), PLoS ONE, 9, 11, 2014. Crossref
-
Sun Cheng-Cao, Li Shu-Jun, Chen Zhen-Long, Li Guang, Zhang Qian, Li De-Jia, Expression and Prognosis Analyses of Runt-Related Transcription Factor Family in Human Leukemia, Molecular Therapy - Oncolytics, 12, 2019. Crossref
-
Langebrake Claudia, Günther Kalle, Lauber Jürgen, Reinhardt Dirk, Preanalytical mRNA Stabilization of Whole Bone Marrow Samples, Clinical Chemistry, 53, 4, 2007. Crossref
-
Ng Cherry Ee Lin, Yokomizo Tomomasa, Yamashita Namiko, Cirovic Branko, Jin Hao, Wen Zilong, Ito Yoshiaki, Osato Motomi, A Runx1 Intronic Enhancer Marks Hemogenic Endothelial Cells and Hematopoietic Stem Cells , Stem Cells, 28, 10, 2010. Crossref
-
Seif Alix E., Lange Beverly J., Biegel Jaclyn A., Nichols Kim E., Heritable predisposition to childhood hematologic malignancies, in Childhood Leukemias, 2012. Crossref
-
Wickrema A, Crispino J D, Erythroid and megakaryocytic transformation, Oncogene, 26, 47, 2007. Crossref
-
Gil-Yarom Naama, Radomir Lihi, Sever Lital, Kramer Matthias P., Lewinsky Hadas, Bornstein Chamutal, Blecher-Gonen Ronnie, Barnett-Itzhaki Zohar, Mirkin Vita, Friedlander Gilgi, Shvidel Lev, Herishanu Yair, Lolis Elias J., Becker-Herman Shirly, Amit Ido, Shachar Idit, CD74 is a novel transcription regulator, Proceedings of the National Academy of Sciences, 114, 3, 2017. Crossref
-
Koh C P, Wang C Q, Ng C E L, Ito Y, Araki M, Tergaonkar V, Huang G, Osato M, RUNX1 meets MLL: epigenetic regulation of hematopoiesis by two leukemia genes, Leukemia, 27, 9, 2013. Crossref