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Critical Reviews™ in Eukaryotic Gene Expression
Fator do impacto: 1.841 FI de cinco anos: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN Imprimir: 1045-4403
ISSN On-line: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukaryotGeneExpr.2016016490
pages 187-198

Aerobic Exercise Modulates the Free Fatty Acids and Inflammatory Response During Obesity and Cancer Cachexia

Alexandre Abilio de Souza Teixeira
Immunometabolism Research Group, Department of Cell Biology and Development − Institute of Biomedical Sciences I − University of Sao Paulo (USP), Sao Paulo, Brazil
Fábio Santos Lira
Immunometabolism Research Group, Department of Cell Biology and Development − Institute of Biomedical Sciences I − University of Sao Paulo (USP), Sao Paulo, Brazil
Gustavo D Pimentel
Faculty of Nutrition − Federal University of Goias (UFG), Goiania, GO, Brazil
Camila Oliveira de Souza
Immunometabolism Research Group, Department of Cell Biology and Development − Institute of Biomedical Sciences I − University of Sao Paulo (USP), Sao Paulo, Brazil
Helena Batatinha
Immunometabolism Research Group, Department of Cell Biology and Development − Institute of Biomedical Sciences I − University of Sao Paulo (USP), Sao Paulo, Brazil
Luana A Biondo
Immunometabolism Research Group, Department of Cell Biology and Development − Institute of Biomedical Sciences I − University of Sao Paulo (USP), Sao Paulo, Brazil
Alex S Yamashita
Department of Physiology and Biophysics − Institute of Biomedical Sciences I − University of Sao Paulo (USP), Sao Paulo, Brazil
Edson A Lima Junior
Immunometabolism Research Group, Department of Cell Biology and Development − Institute of Biomedical Sciences I − University of Sao Paulo (USP), Sao Paulo, Brazil
José Cesar Rosa Neto
Immunometabolism Research Group, Department of Cell Biology and Development − Institute of Biomedical Sciences I − University of Sao Paulo (USP), Sao Paulo, Brazil

RESUMO

White adipose tissue (WAT) is no longer considered a tissue whose main function is the storage of TAG. Since the discovery of leptin in 1994, several studies have elucidated the important role of WAT as an endocrine organ, the source of the adipokines. The low-grade inflammation observed in obese and cancer cachexia patients is explained, at least partially, by the exacerbated release of proinflammatory adipokines. Despite of the recent progress in the characterization of the various adipokines and lipokines produced by WAT, little is known about the mechanisms regulating the secretion of these molecules in different physiological and pathological circumstances. Chronic exercise is a nonpharmacological therapy employed in several chronic diseases and shows an anti-inflammatory effect through the regulation of the cytokine network. In this review, we address the potential mechanisms by which the aerobic physical exercise modulate the production and release of inflammatory adipokines, as well as the inflammation-lipolysis axis in WAT, with special focus in the therapeutic role of exercise in obesity-associated insulin resistance and cancer cachexia.


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