Publicou 6 edições por ano
ISSN Imprimir: 1045-4403
ISSN On-line: 2162-6502
IF:
1.6
5-Year IF:
2.2
Immediacy Index:
0.3
Eigenfactor:
0.00058
JCI:
0.33
SJR:
0.345
SNIP:
0.46
CiteScore™::
2.5
H-Index:
67
Indexed in
Aerobic Exercise Modulates the Free Fatty Acids and Inflammatory Response During Obesity and Cancer Cachexia
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RESUMO
White adipose tissue (WAT) is no longer considered a tissue whose main function is the storage of TAG. Since the discovery of leptin in 1994, several studies have elucidated the important role of WAT as an endocrine organ, the source of the adipokines. The low-grade inflammation observed in obese and cancer cachexia patients is explained, at least partially, by the exacerbated release of proinflammatory adipokines. Despite of the recent progress in the characterization of the various adipokines and lipokines produced by WAT, little is known about the mechanisms regulating the secretion of these molecules in different physiological and pathological circumstances. Chronic exercise is a nonpharmacological therapy employed in several chronic diseases and shows an anti-inflammatory effect through the regulation of the cytokine network. In this review, we address the potential mechanisms by which the aerobic physical exercise modulate the production and release of inflammatory adipokines, as well as the inflammation-lipolysis axis in WAT, with special focus in the therapeutic role of exercise in obesity-associated insulin resistance and cancer cachexia.
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Lira Fabio Santos, dos Santos Thaislaine, Caldeira Renan Santos, Inoue Daniela S., Panissa Valéria L. G., Cabral-Santos Carolina, Campos Eduardo Z., Rodrigues Bruno, Monteiro Paula A., Short-Term High- and Moderate-Intensity Training Modifies Inflammatory and Metabolic Factors in Response to Acute Exercise, Frontiers in Physiology, 8, 2017. Crossref
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Silva Bruna S.A., Lira Fábio S., Ramos Dionei, Uzeloto Juliana S., Rossi Fabrício Eduardo, Freire Ana Paula C.F., Silva Rebeca N., Trevisan Iara B., Gobbo Luis Alberto, Ramos Ercy M.C., Severity of COPD and its relationship with IL-10, Cytokine, 106, 2018. Crossref
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Nono Nankam Pamela A., Mendham Amy E., De Smidt Melony F., Keswell Dheshnie, Olsson Tommy, Blüher Matthias, Goedecke Julia H., Changes in systemic and subcutaneous adipose tissue inflammation and oxidative stress in response to exercise training in obese black African women, The Journal of Physiology, 598, 3, 2020. Crossref
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Minuzzi Luciele Guerra, Teixeira Ana Maria, Thomatieli-Santos Ronaldo V., Rosa-Neto Jose C., Lira Fabio S., Immunometabolism and Covid-19: Could Lifelong Exercise Training Have a Protective Effect?, Immunometabolism, 3, 1, 2021. Crossref
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Rosa-Neto José Cesar, Silveira Loreana Sanches, Endurance Exercise Mitigates Immunometabolic Adipose Tissue Disturbances in Cancer and Obesity, International Journal of Molecular Sciences, 21, 24, 2020. Crossref
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Cabral-Santos Carolina, Silveira Loreana Sanches, Chimin Patricia, Rosa-Neto José Cesar, Lira Fábio Santos, Moderate aerobic exercise-induced cytokines changes are disturbed in PPARα knockout mice, Cytokine, 134, 2020. Crossref
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Gerdle Björn, Bäckryd Emmanuel, Falkenberg Torkel, Lundström Erik, Ghafouri Bijar, Changes in inflammatory plasma proteins from patients with chronic pain associated with treatment in an interdisciplinary multimodal rehabilitation program – an explorative multivariate pilot study, Scandinavian Journal of Pain, 20, 1, 2019. Crossref
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Gerosa-Neto José, Monteiro Paula Alves, Inoue Daniela Sayuri, Antunes Barbara Moura, Batatinha Helena, Dorneles Gilson Pires, Peres Alessandra, Rosa-Neto José Cesar, Lira Fabio Santos, High- and moderate-intensity training modify LPS-induced ex-vivo interleukin-10 production in obese men in response to an acute exercise bout, Cytokine, 136, 2020. Crossref
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Zhao Tong, Guo Bing-jie, Xiao Chu-lan, Chen Jiao-jiao, Lü Can, Fang Fan-fu, Li Bai, Aerobic exercise suppresses hepatocellular carcinoma by downregulating dynamin-related protein 1 through PI3K/AKT pathway, Journal of Integrative Medicine, 19, 5, 2021. Crossref
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Huang Zhengxi, Tang Jialing, Ji Kai, Exercise prevents HFD-induced insulin resistance risk: involvement of TNF-α level regulated by vagus nerve-related anti-inflammatory pathway in the spleen, Diabetology & Metabolic Syndrome, 13, 1, 2021. Crossref
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Del Fabbro Egidio, Orr Tamara A., Stella Susan M., Practical approaches to managing cancer patients with weight loss, Current Opinion in Supportive & Palliative Care, 11, 4, 2017. Crossref
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Feng Lin, Huang Feiyun, Ma Yinan, Tang Jialing, The Effect of High-Fat Diet and Exercise Intervention on the TNF-α Level in Rat Spleen, Frontiers in Immunology, 12, 2021. Crossref
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