Inscrição na biblioteca: Guest
Portal Digital Begell Biblioteca digital da Begell eBooks Diários Referências e Anais Coleções de pesquisa
Critical Reviews™ in Eukaryotic Gene Expression
Fator do impacto: 1.734 FI de cinco anos: 1.848 SJR: 0.627 SNIP: 0.516 CiteScore™: 1.96

ISSN Imprimir: 1045-4403
ISSN On-line: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukaryotGeneExpr.2015013572
pages 163-174

Bacteria-Containing Vacuoles: Subversion of Cellular Membrane Traffic and Autophagy

Bor Luen Tang
Department of Biochemistry, Yong Loo Lin School of Medicine, National University Health System, Singapore, and NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore

RESUMO

Intracellular bacterial pathogens drive the formation of host membrane-derived pseudo-organelles that facilitate their replication, survival, or dormancy. The formation and maintenance of these bacteria-containing vacuoles (BCVs) are dependent on the bacteria's ability to usurp the host's intracellular membrane system, in particular dynamic compartments involved in exo-/endocytic membrane traffic and autophagy. Bacteria are typically internalized by phagocytosis, and the compartment matures through endosomal fusion. The bacteria-containing phagosome/endosome often becomes the base for BCV formation. Diverse strategies used by different bacterial pathogens prevent the BCV from being destroyed via the endolysosomal pathway. Furthermore, bacterial survival or proliferation in BCVs could be augmented by host membrane transport processes subverted by secreted bacterial factors, which facilitate the acquisition of membrane sources and nutrients. BCVs may be targeted for destruction by autophagy, and various facultative and obligate intracellular bacteria have evolved ways to evade or even exploit autophagy. Here we review examples of bacterial subversion of host cellular membrane transport and autophagy machinery for a productive invasion.


Articles with similar content:

Nuclear Import and Export: Transport Factors, Mechanisms and Regulation
Critical Reviews™ in Eukaryotic Gene Expression, Vol.9, 1999, issue 2
Junona Moroianu

MicroRNAs: Cobblestones on the Road to Cancer Metastasis
Critical Reviews™ in Oncogenesis, Vol.18, 2013, issue 4
Valentina Profumo, Paolo Gandellini

Mannosylated Constructs as a Platform for Cell-Specific Delivery of Bioactive Agents
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.35, 2018, issue 2
Sanjay Tiwari

Neural Tissue Engineering and Biohybridized Microsystems for Neurobiological Investigation In Vitro (Part 1)
Critical Reviews™ in Biomedical Engineering, Vol.39, 2011, issue 3
D. Kacy Cullen, Jelena Vukasinovic, Michelle C. LaPlaca, Varadraj N. Vernekar, John A. Wolf

Formulation for Transfollicular Drug Administration: Some Recent Advances
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.14, 1997, issue 3
Brigitte Illel