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Critical Reviews™ in Eukaryotic Gene Expression
Fator do impacto: 1.841 FI de cinco anos: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN Imprimir: 1045-4403
ISSN On-line: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukaryotGeneExpr.2014007798
pages 55-75

MicroRNAs in Bladder Cancer: Expression Profiles, Biological Functions, Regulation, and Clinical Implications

Zhaoqi Shi
Department of General Surgery, 1st Affiliated Hospital of Xi'an Jiao Tong University, Xi'an, 710061, Shaan'xi Province, China
Qingxia Wei
Department of Development and Stem Cell Biology, The Hospital for Sick Children, University of Toronto, Toronto, M5G1X8, ON, Canada
Mingxin Zhang
Department of Gastroenterology, Tangdu Hospital, Fourth Military Medical University, Xi'an,Shaanxi, China
Junjun She
Department of General Surgery, 1st Affiliated Hospital of Xi'an Jiao Tong University, Xi'an, 710061, Shaan'xi Province, China

RESUMO

Bladder cancer (UBC) is a common cancer worldwide and has a high rate of recurrence and progression despite systemic therapy. The molecular mechanisms of UBC are not completely understood. MicroRNAs are noncoding RNA molecules of approximately 23 nucleotides that play important roles in multiple steps during the progression of UBC. Here, we review the expression profiles of miRNAs and their biological functions, regulation, and clinical implications in UBC. Either down-regulation or up-regulation of miRNAs occurs in UBC through epigenetic changes or defects of the biogenesis apparatus. Deregulation of miRNAs is involved in cell-cycle arrest, apoptosis, proliferation, metastasis, drug resistance, and other functions in UBC. A number of miRNAs, including urine miRNAs, have been associated with tumor type, stage, or patient survival, and miRNAs might be developed as diagnostic or prognostic markers. Better understanding of the roles of miRNAs in UBC will shed light on the molecular mechanisms of UBC.