Inscrição na biblioteca: Guest
Portal Digital Begell Biblioteca digital da Begell eBooks Diários Referências e Anais Coleções de pesquisa
Critical Reviews™ in Eukaryotic Gene Expression
Fator do impacto: 1.841 FI de cinco anos: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN Imprimir: 1045-4403
ISSN On-line: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v9.i3-4.20
pages 175-182

Evolution of Transcriptional Control from Prokaryotic Beginnings to Eukaryotic Complexities

Lili Huang
Dana Farber Cancer Institute, 44 Binney St., Boston, MA 02115
Rong J. Guan
Dana Farber Cancer Institute, 44 Binney St., Boston, MA 02115
Arthur B. Pardee
Dana Farber Cancer Institute, 44 Binney St., Boston, MA 02115

RESUMO

Mechanisms for regulating gene transcription became increasingly complex as organisms evolved. In prokaryotes the relatively simple mechanism of repression is based on a few proteins that bind to specific DNA sequences in a ligand-dependent fashion. In eukaryotes large complexes that include ligand binding proteins regulate transcription. Lower eukaryotes developed an additional level of control based on protein complexes that include modifying enzymes. The DNA/histone complex, in combination with gene-specific transcriptional factors, is the basis of gene regulation in eukaryotes. Higher eukaryotes took regulation a level further by methylating CpGs in promoter sequences of DNA, thereby allowing binding of histone deacetylases and inhibiting transcription. Finally, long-lasting "superrepression" provides another mechanism for coordinate transcriptional regulation of large blocks of genes.


Articles with similar content:

Control of Chromatin Remodeling
Critical Reviews™ in Eukaryotic Gene Expression, Vol.10, 2000, issue 3&4
Mariko Moniwa, James R. Davie
Cell-Context Dependent TCF/LEF Expression and Function: Alternative Tales of Repression, De-Repression and Activation Potentials
Critical Reviews™ in Eukaryotic Gene Expression, Vol.21, 2011, issue 3
Catherine D. Mao, Stephen W. Byers
Chromosome Fragility and Instability in Human Cancer
Critical Reviews™ in Oncogenesis, Vol.5, 1994, issue 2-3
Nicholas C. Popescu
Role of Parathyroid Hormone (PTH) and PTH-related Protein (PTHrP) in Regulating Mineral Homeostasis during Fetal Development
Critical Reviews™ in Eukaryotic Gene Expression, Vol.20, 2010, issue 3
Charlene S. Simmonds , Christopher S. Kovacs
Control of Osteoclast Differentiation
Critical Reviews™ in Eukaryotic Gene Expression, Vol.8, 1998, issue 1
G. David Roodman, Sakamuri V. Reddy