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International Journal of Physiology and Pathophysiology
SJR: 0.116

ISSN Imprimir: 2155-014X
ISSN On-line: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

International Journal of Physiology and Pathophysiology

DOI: 10.1615/IntJPhysPathophys.v5.i1.90
pages 83-96

Contribution of Neural Stem Cells to Regeneration of the Central Nervous System

Oksana A. Rybachuk
Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
Tetyana A. Pivneva
Bogomoletz Institute of Physiology National Academy of Sciences of Ukraine, Kyiv; State Key Laboratory of Molecular and Cellular Biology, Bogomolets Institute of Physiology, Kyiv, Ukraine


The central nervous system (CNS) of adult mammals, including humans, serves a typical example of organs that are not restored. However, currently, innovative treatment options aimed at regenerating of damaged CNS tissues have been attracting the growing interest. These options are based on the latest achievements in the field of stem cells and neurology. The recapitulation of normal neural development has become a vital strategy for CNS regeneration. Normal development of the CNS is triggered by induction of the stem cells in it, in other words, neural stem cells (NSCs). Thus, introduction or mobilization of NSCs could be expected to regenerate the CNS through both activation of endogenous regenerative capacity and transplantation of NSCs. This review elucidates recent data on the progress in basic stem cell biology, as well as the mechanisms of NSCs' ontogenic changes, the prospective of identification, potential differentiation, and their therapeutic applications have been elucidated.

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