Inscrição na biblioteca: Guest
International Journal of Physiology and Pathophysiology

Publicou 4 edições por ano

ISSN Imprimir: 2155-014X

ISSN On-line: 2155-0158

SJR: 0.116

Alcohol-Associated Suppression of Strength Response by Musculus Gastrocnemius Caput Mediale in Rats with Critical Vascular Ischemia of Hind Limbs

Volume 6, Edição 3, 2015, pp. 231-248
DOI: 10.1615/IntJPhysPathophys.v6.i3.70
Get accessGet access

RESUMO

The change in m. gastrocnemius caput mediale strength response in alcoholic rats was studied in conditions of experimentally induced critical vascular ischemia of hind limbs. The experiment was performed on 30 male 5 months old Wistar rats weighing 145 - 150 g. Chronic alcohol intoxication of the animals was induced by intragastric delivery of 40% ethyl alcohol for 30 days. Unilateral vascular ischemia was induced by ligating a. femoralis. The mechanical activity of the muscle was registered in isometric contraction under conditions of applied stimulation. To describe the change in muscle strength response to each tetanic contraction, we calculated tetanic force, time to tetanus peak, fusion and fatigue indices. Also, for the last muscle contraction in each tetanic contraction, we calculated the time of contraction, the time of half-relaxation and speed-force index. The alcohol-associated suppression of m. gastrocnemius strength response in alcoholic rats is proved by a low initial tetanus force, which is 50% of the muscle initial force in the controls and non-alcoholic rats. The rate of decrease in the muscle tetanic force during the experiment with alcoholic rats proved to be greater than that in non-alcoholic rats. This fact together with the low values of isometric force developed by the muscle evidences that muscle atrophy in the animals is caused by alcohol. However, no pronounced differences have been found for the time of attaining tetanic force peak and fusion index for alcoholic rats in comparison with non-alcoholic animals. The analysis of time course of the last muscular contraction in tetanus has not revealed any profound change in duration of intervals between contractility in the tetanus. However, we have found reliable changes in the direction of muscle force development: in alcoholic and non-alcoholic rats the muscle develops force at an acute angle in comparison with the controls, which indicates ischemia-associated destabilization of myofibrils. The obtained results show the gathering evidence of the synergy of ethyl alcohol myotoxic effects and destructive influence of vascular ischemia by reducing contractility of m. gastrocnemius in alcoholic rats, which results in intensified ischemia-associated motor dysfunction.

Última edição

Systemic Toxic Dental Sealant-Induced Effect on Nervous Tissue in vitro O. A. Znachkova, Irina V. Lushnikova, Galina G. Skibo, M. Y. Antonenko, Nana V. Voitenko Impact of Various Polyphenols on Disturbance of Cholesterol Metabolism under Insulin Resistance V. P. Fylymonenko, A. L. Zagayko Target Correction of Mitochondrial Dysfunction in Parkinson's Disease by Capicor Iryna M. Mankovska, Kateryna V. Rosova, Olga O. Gonchar, Valentina I. Nosar, Larisa. V. Bratus, Tetyana I. Drevitska, Ivan D. Glazyrin, Nina V. Karasevich, Iryna M. Karaban Changes in Ongoing Activity and Electrophysiological Characteristics of the Rat Retinal Ganglion Cells in Diabetes Mellitus N. Ya. Martyniuk, V. Yu. Maslov, Helen E. Purnyn, Svetlana A. Fedulova, Nikolai S. Veselovsky Sex Characteristics of Hydrogen Sulfide Effect on Ischemia-Reperfusion in Rat Myocardium Andrii V. Melnyk, Nataliia V. Zaichko, Oleksii A. Khodakovskyi, Olga V. Khodakivska Cardiohemodynamic Changes in Focal Cerebral Ischemia Roman R. Sharipov, Nataliya A. Dorofeyeva, Vadim F. Sagach Cerebral Hemodynamics and Electroencephalographic Pattern in Patients with Symptomatic Epilepsy at Combined Treatment with Transcranial Direct Current Stimulation Kateryna V. Yatsenko Physiological Endurance of Skeletal Muscle Increases under C60 Fullerene Application before Physical Load Tetyana Yu. Matvienko, Danylo Zavodovskiy, Iryna V. Mishchenko, Kateryna I. Bogutska, Yuriy I. Prylutskyy, Sofia Paradizova, Larisa Bezuh, Uwe Ritter, Peter Scharff Possible Mechanisms Underlying Association between Thyroiditis and Thyroid Papillary Carcinoma Tamara M. Myshunina, Mykola D. Tronko Index, Volume 9, 2018
Portal Digital Begell Biblioteca digital da Begell eBooks Diários Referências e Anais Coleções de pesquisa Políticas de preços e assinaturas Begell House Contato Language English 中文 Русский Português German French Spain