RESUMO

The results of Methylenetetrahydrofolate Reductase (MTHFR) gene C677T (rs1801133) polymorphism assessment in 170 patients with ischemic atherothrombotic stroke (IATS) and 124 healthy subjects (control group) have been submitted. It has been shown that in patients with IATS, frequencies of main homozygotes (CC), heterozygotes (CT) and minor homozygotes (TT) are 52.4, 35.9, 11.8% (in control − 46.0, 48.4, 5.6%, P = 0.044 by χ² -test). TT homozygotes have a greater chance of developing IATS than carriers of main C-allele (CT + CC) (OR = 2.3, CI + 0.911 − 5.449, P = 0.049). In the representatives of Ukrainian population, there is a relationship between the frequency of MTHFR gene C677T polymorphism genotypes and the risk of IATS. This connection is manifested in male patients, in persons with normal blood pressure, and in people who do not have the habit of smoking. The patient's gender, body mass index, blood pressure and smoking affect the level of the studied polymorphism association with stroke.