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International Journal of Physiology and Pathophysiology

Publicou 4 edições por ano

ISSN Imprimir: 2155-014X

ISSN On-line: 2155-0158

SJR: 0.116

Features of Histostructural Changes in Rat Cerebral Cortex in Hemorrhagic Stroke Modeling

Volume 4, Edição 2, 2013, pp. 113-121
DOI: 10.1615/IntJPhysPathophys.v4.i2.40
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RESUMO

The features of pathological changes in modeling the primary and recurrent acute hemorrhagic stroke were studied in rats. The differences in the pharmacological activity of the medicinal drugs in acute stroke have been revealed. The drugs increased survival of the neurons in both hemispheres of rat cerebrum at right-side primary and recurrent hemorrhagic stroke. In recurrent stroke, the number of degenerative neurons has been shown to be (25.5 ± 0.8) cells/mm2, after administration of cerebrolysin, cortexin and cerebral, the number of degenerative neurons is (17.6 ± 1.7) cells/mm2, (18.0 ± 0.9) cells/mm2, and 10.7 ± 0.4) cells/mm2, respectively, while in control animals, it do not exceed 2% and averages (1.5 ± 0.1) cells/mm2. An analysis of morphological and statistical data has shown that cortexin and cerebral are the most effective remedies under the primary and recurrent hemorrhagic stroke, while the latter has more pronounced effect.

CITADO POR
  1. Dovgan I. M., ULTRASTRUCTURAL CHANGES IN RAT SCIATIC NERVE AFTER HEMORRHAGIC STROKE, World of Medicine and Biology, 15, 67, 2019. Crossref

  2. Dovgan I. M., Melnyk N. O., Labunets I. F., Utko N. A., Savosko S. I., THE ACTIVITY OF ANTIOXIDANT ENZYMES IN RAT SCIATIC NERVE FOLLOWING A HEMORRHAGIC STROKE, World of Medicine and Biology, 13, 61, 2017. Crossref

  3. Motorna Natalia, Structural changes in liver under conditions of experimental hemorrhagic stroke, Current Issues in Pharmacy and Medical Sciences, 32, 2, 2019. Crossref

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