Inscrição na biblioteca: Guest
Portal Digital Begell Biblioteca digital da Begell eBooks Diários Referências e Anais Coleções de pesquisa
International Journal of Physiology and Pathophysiology
SJR: 0.116

ISSN Imprimir: 2155-014X
ISSN On-line: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

International Journal of Physiology and Pathophysiology

DOI: 10.1615/IntJPhysPathophys.v9.i4.20
pages 295-301

Impact of Various Polyphenols on Disturbance of Cholesterol Metabolism under Insulin Resistance

V. P. Fylymonenko
National University of Pharmacy, Kharkiv Ukraine
A. L. Zagayko
National University of Pharmacy, Kharkiv Ukraine

RESUMO

The effects of therapeutic and prophylactic administration of quercetin, epigallocatechin gallate, and grape polyphenolic extract on changes in cholesterol metabolism in the rat blood serum under insulin resistance were studied. The development of atherogenic dislipoproteinemia has been revealed as evidenced by the accumulation of total cholesterol (2.12 times) due to the growth of the content of very low-density lipoprotein cholesterol (1.75 times), the decrease in the concentration of high-density lipoprotein cholesterol (2.6 times), and the increase in the atherogenicity index (8.8 times) in animals on a high-fructose diet. The use of all examined polyphenols in different ways normalized cholesterol metabolism. Grape polyphenolic extract has shown more pronounced protective properties, obviously, due to more diverse composition and, accordingly, mechanisms of insulin resistance correction.