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International Journal of Physiology and Pathophysiology
SJR: 0.106

ISSN Imprimir: 2155-014X
ISSN On-line: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

International Journal of Physiology and Pathophysiology

DOI: 10.1615/IntJPhysPathophys.v3.i4.80
pages 363-370

Effect of ω-3 Polyunsaturated Fatty Acids on the Heart Mitochondria Respiration in Experimental Diabetes Mellitus

Anna S. Zhukovska
Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
Angela M. Shysh
Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
Oleksiy O. Moibenko
International Center for Astronomical and Medico-Biological Research, National academy of Sciences of Ukraine, Department of Experimental Cardiology, Department of General and Molecular Pathophysiology, Bogomoletz institute of Physiology, Kyiv, Ukraine

RESUMO

We studied the effect of ω-3 polyunsaturated fatty acids (PUFAs) on the heart mitochondria respiration and fatty acid composition in tissue homogenates of the rat heart in streptozotocin-induced diabetes mellitus (DM), modeled by a single intraperitoneal administration of 50 mg / kg streptozotocin. Application of these acids significantly increased the active mitochondrial respiration V3 by 63.7%, controlled respiration V4 by 30.33%, but the phosphorylation efficiency coefficient (ADP/O) reduced to virtually the control level (by 23.8%) in animals with streptozotocin-induced diabetes mellitus. In addition, the ω-3 PUFA-induced changes in fatty acid composition were observed in the heart cellular membranes in diabetes mellitus. The obtained results make it possible to conclude that the latter have a positive affect on the functional parameters of the mitochondria, due to stabilization of cell membranes of the heart in rats with diabetes mellitus.


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