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ISSN Imprimir: 2155-014X
ISSN On-line: 2155-0158
The Frequency of Allelic Polymorphism of Matrix Gla-Protein Gene in Patients with Acute Coronary Syndrome
RESUMO
The frequency of allelic polymorphisms of the matrix Gla-protein (MGP) gene, a key protein regulator of calcification, was determined in 115 patients with acute coronary syndrome (ACS) and in 110 practically healthy people (control group). It has been found that the ratio of major homozygotes, heterozygotes and minor homozygotes, when testing T−138 → C MGP promoter polymorphism in patients with ACS was: 59.8, 32.7, 7.5% (in control group it was 58.7, 36.7, 4.6%, P > 0.05); for G7 → A promoter polymorphism it was 42.1, 45.6 and 12.3%, and 41.8, 54.5, 3.6%, respectively (P < 0.05 by χ2-test), and for Thr83 → Ala exon 4 polymorphism it was 42.5, 43.5 and 13.9% compared with 43.9, 45.9, 10.2% in the control (P > 0.05). The results have proved that MGP A/A variant of MGP promoter (G7 → A polymorphism) is associated with increased risk of ACS in Ukrainian population, and it indicates that the intensity of calcification affects the development of atherosclerotic injury of coronary arteries.