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International Journal of Physiology and Pathophysiology
SJR: 0.116

ISSN Imprimir: 2155-014X
ISSN On-line: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

International Journal of Physiology and Pathophysiology

DOI: 10.1615/IntJPhysPathophys.v9.i3.50
pages 229-238

Predictors of Left Ventricular Myocardial Structural Remodeling in Patients with Atrial Fibrillation

Alexey Goryachyi
Ukrainian Research Institute of Transport Medicine, Odessa, Ukraine
Yuryi Karpenko
Odessa Regional Clinical Hospital, Odessa, Ukraine
E. Levchenko
Odessa Regional Clinical Hospital, Odessa, Ukraine
Anatoliy I. Gozhenko
Ukrainian Research Institute of Transport Medicine, Odessa, Ukraine

RESUMO

The content of matrix metalloproteinase-9 (MMP-9) in the blood serum was studied as an independent predictor of atrial fibrillation recurrence after radiofrequency catheter ablation (CRA). 35 patients with long-persistent form of atrial fibrillation (LPAF) lasting more than one year and resistant to drug therapy were examined. For all patients, MMP-9 concentration was measured before the CRA procedure, and its association with arrhythmia recurrence was assessed at the end of postoperative period. An enzyme-linked immunosorbent assay with double enzyme labeled antibodies was used for this purpose. The period of observation was (16.2 ± 5.7) months, and in 12 (34.3%) patients, there was arrhythmia relapse after the ablation procedure. The basal content of MMP-9 was higher in patients with relapsing arrhythmia (261.3 ± 35.3 versus (202.46 ± 27.6) ng/ml in control (P < 0.05)). Multivariate analysis showed that indicators such as MMP-9 content, the history of atrial fibrillation, and the left atrium diameter were independent predictors of arrhythmia recurrence.


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