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International Journal of Physiology and Pathophysiology

Publicou 4 edições por ano

ISSN Imprimir: 2155-014X

ISSN On-line: 2155-0158

SJR: 0.116

Cardiohemodynamics and Efficiency of Frank − Starling Mechanism in Aging

Volume 6, Edição 4, 2015, pp. 331-337
DOI: 10.1615/IntJPhysPathophys.v6.i4.70
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RESUMO

In adult and old Wistar rats, we studied cardio-hemodynamics and efficiency of Frank − Starling mechanisms. To evaluate systolic and diastolic function of the heart in vivo, the left-ventricular pressure and volume with visualization of the curves during the cardiac cycle were recorded using ultra miniature catheter 2F (Millar Instruments, USA). We have revealed left ventricular diastolic dysfunction and impaired relaxation of the heart in old rats, which is evidenced by the reduction in the maximum rate of left ventricular pressure generation under an increase in both end-diastolic stiffness and active relaxation constant. The results indicate that the efficiency of Frank-Starling mechanism (ΔSV/ΔEDV) decreases in old rats. At the same time, oxygen consumption in old rats increases by 70%, and stroke work of the heart increases 1.7 times. It means that despite the similar stroke volume, the heart of old rats perform more stroke work, with greater oxygen consumption, indicating that the heart of old rats works less effectively.

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  1. Dorofeyeva Natalya, Drachuk Konstantin, Rajkumar Rajasekaran, Sabnis Omkar, Sagach Vadim, H 2 S donor improves heart function and vascular relaxation in diabetes , European Journal of Clinical Investigation, 51, 1, 2021. Crossref

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