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International Journal of Physiology and Pathophysiology

Publicou 4 edições por ano

ISSN Imprimir: 2155-014X

ISSN On-line: 2155-0158

SJR: 0.116

The Ratio of P53-Proapoptotic and BCL-2 Anti-Apoptotic Activities in the Hippocampus of Rats with Cerebral Ischemia − Reperfusion and Experimental Diabetes

Volume 8, Edição 4, 2017, pp. 319-328
DOI: 10.1615/IntJPhysPathophys.v8.i4.40
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RESUMO

Dynamics of the balance of indices of pro- and anti-apoptotic processes (p53 and Bcl-2, respectively) in the hippocampus of rats with experimental diabetes mellitus (DM), complicated by incomplete global cerebral ischemia-reperfusion was investigated. P53-mediated pro-apoptotic processes in animals without DM were found to be activated after 20 minutes of ischemia and 1 hour of reperfusion in all fields of the hippocampus against the background of increasing Bcl-2-mediated anti-apoptotic processes in CA1, CA2, CA4 fields and their depression in the CA3 field. In the early post-ischemic period the activity of p53- dependent processes in rats with DM significantly exceeds that one in non-diabetic rats in the fields CA1, CA3, CA4 (p53-IRM area increases by 110, 60 and 27%, respectively), but it is significantly lower than that in CA2 field. On the 12th day of post-ischemic period, the activation of apoptosis in CA1 field occurs against the background of inert anti-apoptotic processes both in diabetic rats and animals without diabetes, but the indicators characterizing apoptotic activity in rats with diabetes are higher (specific contents of p53 protein and p53-IRM area increase by 38 and 43%, respectively). During this period certain depression of anti-apoptotic processes was found in animals without diabetes mellitus with inconsiderable predominance of pro-apoptotic ones in CA2 field, whereas depression of both mechanisms was determined against the background of diabetes mellitus. Anti-apoptotic processes appeared to be more intensive. In CA3 field of rats without diabetes mellitus the activity of pro-apoptotic processes was preserved and depression of anti-apoptotic processes became deeper. In rats with DM, inhibition of both mechanisms was found with significant depression of anti-apoptotic processes. On the 12th day of experiment in CA4 field the most balanced relationship between the studied processes was observed due to their parallel and unidirectional changes both in the rats with and without diabetes mellitus. The results are indicative of a modifying effect of DM on susceptibility of hippocampal fields to ischemic-reperfusion injury.

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