Inscrição na biblioteca: Guest
International Journal of Physiology and Pathophysiology

Publicou 4 edições por ano

ISSN Imprimir: 2155-014X

ISSN On-line: 2155-0158

SJR: 0.116

Subunit-Specific Modulation of α1 Glycine Receptors by Ginkgolic Acid

Volume 8, Edição 4, 2017, pp. 291-297
DOI: 10.1615/IntJPhysPathophys.v8.i4.10
Get accessGet access

RESUMO

Ginkgo biloba extract is a multicomponent pharmacological agent widely used in neurological disorders therapy. Ginkgolic acid, a constituent of lipophylic Ginkgo biloba extract, is known to have numerous biological activities. In the present study, using whole-cell configuration of patch-clamp recording, we have analyzed the effect of ginkgolic acid on glycine receptors, postsynaptic ion channel proteins that provide the fast inhibitory neurotransmission in nervous system of vertebrates. The experiments were performed on cultured chinese hamster ovary cells (CHO cells), transfected with α1 or α2 subunits of glycine receptor. Ionic currents were induced by the fast application of different glycine concentrations. After 20 − 40 sec of pre-treatment with ginkgolic acid (25μM), currents mediated by α1 glycine receptors reversibly increased from (364 ± 49) pA, (n = 34) to (846 ± 134) pA, (n = 34). EC50 for glycine has changed from (36 ± 6) μM, in control, to (17 ± 2) μM under ginkgolic acid action. In contrast, the application of ginkgolic acid on glycine receptors formed by α2 subunits did not provoke potentiation. Our results demonstrate that ginkgolic acid is a subunit-specific modulator of glycine receptors. The mechanisms of the ginkgolic acid action on glycine receptors require further investigation.

Última edição

Systemic Toxic Dental Sealant-Induced Effect on Nervous Tissue in vitro O. A. Znachkova, Irina V. Lushnikova, Galina G. Skibo, M. Y. Antonenko, Nana V. Voitenko Impact of Various Polyphenols on Disturbance of Cholesterol Metabolism under Insulin Resistance V. P. Fylymonenko, A. L. Zagayko Target Correction of Mitochondrial Dysfunction in Parkinson's Disease by Capicor Iryna M. Mankovska, Kateryna V. Rosova, Olga O. Gonchar, Valentina I. Nosar, Larisa. V. Bratus, Tetyana I. Drevitska, Ivan D. Glazyrin, Nina V. Karasevich, Iryna M. Karaban Changes in Ongoing Activity and Electrophysiological Characteristics of the Rat Retinal Ganglion Cells in Diabetes Mellitus N. Ya. Martyniuk, V. Yu. Maslov, Helen E. Purnyn, Svetlana A. Fedulova, Nikolai S. Veselovsky Sex Characteristics of Hydrogen Sulfide Effect on Ischemia-Reperfusion in Rat Myocardium Andrii V. Melnyk, Nataliia V. Zaichko, Oleksii A. Khodakovskyi, Olga V. Khodakivska Cardiohemodynamic Changes in Focal Cerebral Ischemia Roman R. Sharipov, Nataliya A. Dorofeyeva, Vadim F. Sagach Cerebral Hemodynamics and Electroencephalographic Pattern in Patients with Symptomatic Epilepsy at Combined Treatment with Transcranial Direct Current Stimulation Kateryna V. Yatsenko Physiological Endurance of Skeletal Muscle Increases under C60 Fullerene Application before Physical Load Tetyana Yu. Matvienko, Danylo Zavodovskiy, Iryna V. Mishchenko, Kateryna I. Bogutska, Yuriy I. Prylutskyy, Sofia Paradizova, Larisa Bezuh, Uwe Ritter, Peter Scharff Possible Mechanisms Underlying Association between Thyroiditis and Thyroid Papillary Carcinoma Tamara M. Myshunina, Mykola D. Tronko Index, Volume 9, 2018
Portal Digital Begell Biblioteca digital da Begell eBooks Diários Referências e Anais Coleções de pesquisa Políticas de preços e assinaturas Begell House Contato Language English 中文 Русский Português German French Spain