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International Journal of Physiology and Pathophysiology

Publicou 4 edições por ano

ISSN Imprimir: 2155-014X

ISSN On-line: 2155-0158

SJR: 0.116

Effect of Intermittent Hypoxia Trainings on the Functional State of Corticotropin releasing hormone- and β-Endorphin-Synthesizing Neurons of the Rat Paraventricular Nucleus of Hypothalamus

Volume 5, Edição 4, 2014, pp. 291-297
DOI: 10.1615/IntJPhysPathophys.v5.i4.20
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RESUMO

In experiments on rats, it has been shown that hypoxic training results in enhanced immunoreactivity to corticotropin releasing hormone (CRH) and β-endorphin and increased content of these neuropeptides in the paraventricular nucleus (PVN) of the hypothalamus. Whereby, the ratio of the area of the immunoreactive material and the CRH / β-endorphin level, and the coefficient of their content in the PVN did not change significantly compared with the control. Thus, the selected mode of hypoxic effects results in body adaptation, which is manifested as the balanced activity of stress-realizing and stress-limiting systems of rats' hypothalamus.

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