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International Journal of Medicinal Mushrooms
Fator do impacto: 1.423 FI de cinco anos: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Imprimir: 1521-9437
ISSN On-line: 1940-4344

Volumes:
Volume 21, 2019 Volume 20, 2018 Volume 19, 2017 Volume 18, 2016 Volume 17, 2015 Volume 16, 2014 Volume 15, 2013 Volume 14, 2012 Volume 13, 2011 Volume 12, 2010 Volume 11, 2009 Volume 10, 2008 Volume 9, 2007 Volume 8, 2006 Volume 7, 2005 Volume 6, 2004 Volume 5, 2003 Volume 4, 2002 Volume 3, 2001 Volume 2, 2000 Volume 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.2018025329
pages 13-29

Antiproliferative and Antioxidant Activities of Wild Boletales Mushrooms from France

Sylvie Morel
Laboratoire de Botanique, Phytochimie et Mycologie, Faculté de Pharmacie, CEFE UMR 5175 CNRS Université de Montpellier Université Paul-Valéry Montpellier EPHE, Montpellier, France
Stéphanie Arnould
Institut de Recherche en Cancérologie de Montpellier, U1194 INSERM/Université de Montpellier/ICM, Montpellier, France
Manon Vitou
Laboratoire de Botanique, Phytochimie et Mycologie, Faculté de Pharmacie, CEFE UMR 5175 CNRS Université de Montpellier Université Paul-Valéry Montpellier EPHE, Montpellier, France
Frédéric Boudard
Laboratoire d'Immunologie, Faculté de Pharmacie, UMR 95 Qualisud CIRAD Université de Montpellier, Montpellier, France
Caroline Guzman
Laboratoire d'Immunologie, Faculté de Pharmacie, UMR 95 Qualisud CIRAD Université de Montpellier, Montpellier, France
Patrick Poucheret
Laboratoire de Pharmacologie and Physiopathologie Expérimentale, Faculté de Pharmacie, UMR 95 Qualisud CIRAD Université de Montpellier, Montpellier, France
Françoise Fons
Laboratoire de Botanique, Phytochimie et Mycologie, Faculté de Pharmacie, CEFE UMR 5175 CNRS Université de Montpellier Université Paul-Valéry Montpellier EPHE, Montpellier, France
Sylvie Rapior
Laboratoire de Botanique, Phytochimie et Mycologie, Faculté de Pharmacie, CEFE UMR 5175 CNRS Université de Montpellier Université Paul-Valéry Montpellier EPHE, Montpellier, France

RESUMO

We selected edible and inedible mushrooms growing in the Mediterranean area of France to screen their biological activity: Caloboletus calopus, Rubroboletus lupinus, R. pulchrotinctus, R. satanas, Gyroporus castaneus, Suillus luteus, and Omphalotus olearius. Mushrooms were sequentially extracted using cyclohexane, chloroform, ethanol, and water. The antiproliferative activity against the HCT116 colon adenocarcinoma cell line and the antioxidant properties (DPPH radical scavenging assay, Folin-Ciocalteu assay, and oxygen radical absorbance capacity) of the Boletales extracts were evaluated and compared. Among the 28 mushroom extracts evaluated, 11 presented antiproliferative activity against HCT116 cells. These activities were not linked to antioxidant capacity. Among the antioxidant extracts, most were aqueous extracts in the oxygen radical absorbance capacity assay, whereas the highest values on the Folin-Ciocalteu and DPPH assays were noted for chloroform, ethanol, or aqueous extracts, depending on the mushroom species. Further studies are necessary to identify bioactive compounds and to valorize the mushrooms−for edible species, directly as health foods, or, for inedible mushrooms, as ingredients in the pharmaceutical and food industries.


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