Inscrição na biblioteca: Guest
Portal Digital Begell Biblioteca digital da Begell eBooks Diários Referências e Anais Coleções de pesquisa
International Journal of Medicinal Mushrooms
Fator do impacto: 1.423 FI de cinco anos: 1.525 SJR: 0.431 SNIP: 0.716 CiteScore™: 2.6

ISSN Imprimir: 1521-9437
ISSN On-line: 1940-4344

Volumes:
Volume 22, 2020 Volume 21, 2019 Volume 20, 2018 Volume 19, 2017 Volume 18, 2016 Volume 17, 2015 Volume 16, 2014 Volume 15, 2013 Volume 14, 2012 Volume 13, 2011 Volume 12, 2010 Volume 11, 2009 Volume 10, 2008 Volume 9, 2007 Volume 8, 2006 Volume 7, 2005 Volume 6, 2004 Volume 5, 2003 Volume 4, 2002 Volume 3, 2001 Volume 2, 2000 Volume 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.2018025468
pages 201-212

In Vitro Evaluation of the Antiviral Activity of Some Mushrooms from Turkey

Hasan Hüseyin Doğan
Biology Department, Science Faculty, Selçuk University, Campus, Konya, Turkey
Sami Karagöz
Public Health Laboratory, Ministry of Health, Karaman, Turkey
Rüstem Duman
Biology Department, Science Faculty, Selcuk University, Konya, Turkey

RESUMO

Despite considerable recent work to reveal different features of mushrooms species, the few studies of antiviral activities are inadequate and therefore further studies are required. Morchella conica, M. esculenta, Terfezia boudieri, Pleurotus ostreatus, Tricholoma anatolicum, Fomes fomentarius, Laetiporus sulphureus, Phellinus igniarius, Porodaedalea pini, and Pyrofomes demidoffii from Turkey were investigated to reveal their in vitro cytotoxic and anti-herpes simplex virus 1 (HSV-1) activities. The crude methanol extracts (MEs) and aqueous extracts (AEs) of fungal species and acyclovir (ACV) were used. Various dilutions were used to assess the cytotoxic effects of fungal species (50-0.10 mg/mL) and ACV (500-0.98 μg/mL) on uninfected Vero cells. Maximum nontoxic concentrations were determined for all extracts and ACV by comparing the optical densities of their cell controls. The concentration providing 50% protection against the cytopathic effect caused by the virus, extracts, and ACV (EC50) was calculated, and the half-maximal cytotoxic concentration (CC50) and the selectivity index (SI) were determined, the latter as the ratio of CC50 to EC50. While the AEs of F. fomentarius (EC50, 11.22 mg/mL; SI > 4.46), Ph. igniarius (EC50, 9.71 mg/mL; SI > 5.15), and P. pini (EC50, 7.16 mg/mL; SI > 6.98) showed considerable antiherpetic activity, MEs and AEs of the other fungal species did not showed any effects. The EC50 and SI of ACV were determined as 0.20 μg/mL and 3085, respectively. The results demonstrate that F. fomentarius, Ph. igniarius, and P. pini have important anti-HSV-1 activity.


Articles with similar content:

Antimicrobial and Cytotoxic Activities of the Sulphur Shelf Medicinal Mushroom, Laetiporus sulphureus (Agaricomycetes), from Serbia
International Journal of Medicinal Mushrooms, Vol.18, 2016, issue 6
Tatjana P. Stanojkovic, Tatjana D. Kundakovic, Milan Kojic, Marina D. Kolundzic, Marina T. Milenkovic, Nada O. Grozdanic, Miroslav R. Dinic, Natasa E. Golic
Anti-inflammatory Activity of Mycelial Extracts from Medicinal Mushrooms
International Journal of Medicinal Mushrooms, Vol.16, 2014, issue 4
Hong-Yu Xu, Zhenming Lu, Yan Geng, Zheng-Hong Xu, Jin-Song Shi, Shuiling Zhu
Investigations on Antioxidative Potential of Poroid Medicinal Mushroom Porodaedalea pini (Agaricomycetes)
International Journal of Medicinal Mushrooms, Vol.21, 2019, issue 6
Minni Singh, Niharika Kaushal, Navpreet Kaur, Gurpaul Singh Dhingra, Avneet Pal Singh
Secondary Metabolites and Antioxidant Capacity of the Tunisian Lichen Diploschistes ocellatus (Ascomycota)
International Journal of Medicinal Mushrooms, Vol.21, 2019, issue 8
Samira Aschi-Smiti, Mohamed Mendili, Marwa Bannour, Maria Eduarda M. Araújo, Ayda Khadhria, Mark R. D. Seaward
Comparative Antitumor Activity of Jelly Ear Culinary-Medicinal Mushroom, Auricularia auricula-judae (Bull.) J. Schrot. (Higher Basidiomycetes) Extracts Against Tumor Cells In Vitro
International Journal of Medicinal Mushrooms, Vol.14, 2012, issue 4
Md.Ahsanur Reza, Seung-Chun Park, Woo-Sik Jo