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International Journal of Medicinal Mushrooms
Fator do impacto: 1.423 FI de cinco anos: 1.525 SJR: 0.431 SNIP: 0.716 CiteScore™: 2.6

ISSN Imprimir: 1521-9437
ISSN On-line: 1940-4344

Volumes:
Volume 22, 2020 Volume 21, 2019 Volume 20, 2018 Volume 19, 2017 Volume 18, 2016 Volume 17, 2015 Volume 16, 2014 Volume 15, 2013 Volume 14, 2012 Volume 13, 2011 Volume 12, 2010 Volume 11, 2009 Volume 10, 2008 Volume 9, 2007 Volume 8, 2006 Volume 7, 2005 Volume 6, 2004 Volume 5, 2003 Volume 4, 2002 Volume 3, 2001 Volume 2, 2000 Volume 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.v7.i3.660
pages 423-425

Screening Systems for Medicinal Basidiomycetes Antitumor Extracts

Larissa M. Krasnopolskaya
Gause Institute of New Antibiotics, Russian Academy of Medical Sciences, 11 B, Pirogovskaya Str., Moscow 119867, Russia
Igor V. Belitsky
Gause Institute of New Antibiotics, Russian Academy of Medical Sciences, 11 B, Pirogovskaya Str., Moscow 119867, Russia
Anastasia V. Avtonomova
Gause Institute of New Antibiotics, Russian Academy of Medical Sciences, B. Pirigovskaya St., 11,119021 Moscow, Russia
N. Soboleva
Gause Institute of New Antibiotics, B. Pirigovskaya St., 11,119021 Moscow, Russia
Anatoliy I. Usov
Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospect, 47,117913 Moscow, Russia
Elena B. Isakova
Gause Institute of New Antibiotics, Russian Academy of Medical Sciences, B. Pirigovskaya St., 11,119021 Moscow, Russia
Alex Libenzon
Gause Institute of New Antibiotics, B. Pirigovskaya St., 11,119021 Moscow, Russia
Vladimir M. Bukhman
Gause Institute of New Antibiotics, Russian Academy of Medical Sciences, B. Pirigovskaya St., 11,119021 Moscow, Russia

RESUMO

Prevention and treatment of oncological diseases is one of the most important fields of possible practical application of preparations on the basis of medicinal Basidiomycetes. The present experimental data demonstrate the ability of mushrooms to synthesize metabolites, revealing anticarcinogenic effects, possessing antitumor activities due to cytostatic or/and immunostimulating action, and inhibiting the process of metastasis. One of the most important current problems in our view is the development or screening systems for mushroom antitumor preparations, including their effectiveness and cost. The present investigation is the first step in this direction.
Strains of Ganoderma lucidum (W.Curt.:Fr.) Lloyd, Hericium erinaceus (Bull.:Fr.) Pers., Lentinus edodes (Berk.) Singer, Trametes versicolor (L.:Fr.) Pilát, having taxonomic proximity and affiliation with the group of xylosaprotrophes (causing white mould) due to their ability to use lignin, was studied.
The action of extracts of submerged mycelium, fruit bodies, and basidiospores from Russian and Chinese mushroom farm was investigated.
Submerged cultivation was carried out in the Gause Institute of New Antibiotics of Russian Academy of Medical Sciences. The strategy for developing methods of submerged cultivation of the species studied, which secures maximal shortage of cultivation costs owing to possibilities of strain diversity, reduction of process length 2−4 times, and increase of biomass yield was worked out. The methods of submerged culture were developed individually for each studied object and included the mice, and in 9-month-old adult mice antitumor growth was not effected by itself but authentically strengthened the CF effect. A similar effect was observed in adult (5-month-old) mice after oral introduction of G. lucidum mycelium combined extract. Thus, the dependence of the antitumor effect of the mushroom extract on the age of the laboratory animal age was determined.
Some additives were selected to strengthen the antitumor effect of G. lucidum mycelium extracts. The highest self-activity was shown by orally introduced mycelium polysaccharide fractions with various ratios of monosaccharides.
Unlike basidiom extracts, submerged mycelium extracts of Hericium erinaceus showed self-antitumor activity on a solid lymphoma model, resulting in inhibition of tumor growth. This effect was distinctly increased by the single prior introduction of a low dose (50 mg/kg)of CF.


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