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International Journal of Medicinal Mushrooms

Publicou 12 edições por ano

ISSN Imprimir: 1521-9437

ISSN On-line: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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A Newly Isolated Anamorph of the Medicinal Fungus Cordyceps sinensis (Berk.) Sacc. (Ascomycetes): A Review of Its Identification, Cultivation Parameters, Chemical Composition, and Antioxidant and Antitumor Activities

Volume 7, Edição 3, 2005, 409 pages
DOI: 10.1615/IntJMedMushrooms.v7.i3.530
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RESUMO

Cordyceps sinensis (Cs) (DongChongXiaCao in Chinese), is a rare and precious Chinese herb facing a stringent shortage of natural supply (i.e., over-harvesting and continued destruction of habitat) due to increasing world demand. This increasing shortage in supply has driven the price of wild collected Cordyceps up to previously unimaginable levels, making wild collected C. Sinensis the most costly medicinal raw material available today. The cultivated mycelium of the C. sinensis fungi has been shown to significantly lower the cost and has proven to be a feasible alternative to the natural species for herbal medicine, pharmaceutical, and functional food use. Since the mid-1980s there have been a number of different anamorphs of C. sinensis isolated and brought into cultivation. While these modern biotechnologically cultivated anamorphs appear to hold great potential for relieving the worldwide shortage of this valuable medicine, the sheer number of different anamorphs and their widely differing chemical and cultivation parameters pose many questions about the effectiveness and equivalence to the wild collected C. sinensis.
In this work, we investigated and elucidated a fungus species, which was isolated from the wild Cs herb, which we have identified as a new anamorph of Cs. Its UV, IR, and HPLC spectra all exhibit high similarity in chemical composition to those of natural Cs herbs. As in the case of the wild fungus, this fungus (extracted by water or ethanol) exhibits strong antioxidant properties, scavenging free radicals (as shown by DPPH assay), and inhibits lipid peroxidation (shown by TBA assay). It also shows strong antitumor activity in a number of different tumor cell lines, both in vitro and in vivo, and shows potent inhibition of tumor growth in the Murine model.
These results suggest that this newly isolated Cs anamorph more closely mirrors the chemical composition and pharmacological activity of the natural Cs than has any previously identified anamorph, indicating the potential for an improvement upon the existing fungal lines in Cordyceps cultivation. The morphological characteristics, genetic identification, biotechnological potential, and detailed growth parameters in both liquid cultivation and solid state fermentation for this fungal mycelium are fully evaluated and indicate this new anamorph as having great potential as an effective and low-cost substitute for the natural Cs herb.

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