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International Journal of Medicinal Mushrooms
Fator do impacto: 1.423 FI de cinco anos: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Imprimir: 1521-9437
ISSN On-line: 1940-4344

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International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v9.i1.20
pages 7-14

Evaluation of Therapeutic Activity of Hypogeous Ascomycetes and Basidiomycetes from North America

Rita Stanikunaite
Department of Pharmacognosy, The University of Mississippi, University, MS, USA
James M. Trappe
Department of Forest Service, Oregon State University, Corvallis, Oregon 97331-5257, USA
Shabana I. Khan
National Center for Natural Products Research, The University of Mississippi, University, MS, USA
Samir A. Ross
Department of Pharmacognosy and National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, Mississippi 38677


This study is the first broad investigation of therapeutic activities of hypogeous truffles and truffle-like fungi (Ascomycetes and Basidiomycetes) from North America. Twenty-two species from 12 families were evaluated in several biological assays for antimicrobial, antimalarial, antiinflammatory, antioxidant, antituberculosis, and anticancer activities. Biological screening results indicate that 1 species showed antimalarial activity, 11 species were active in antioxidant assay, 9 species were active in antiinflammatory assay, 9 species showed antituberculosis activity, and 2 species showed anticancer activity. Among the screened species, Elaphomyces granulatus, E. muricatus, Geopora clausa, Hymenogaster subalpinus, Melanogaster tuberiformis, Rhizopogon couchii, R. nigrescens, R. pedicellus, R. subaustralis, R. subgelatinosus, and Scleroderma laeve expressed therapeutic activity in more than one assay. Our results indicate that this group of fungi has promising therapeutic activities that could lead to the development of new agents for the treatment and prevention of diseases.