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International Journal of Medicinal Mushrooms

Publicou 12 edições por ano

ISSN Imprimir: 1521-9437

ISSN On-line: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Neurotropic and Trophic Action of Lion's Mane Mushroom Hericium erinaceus (Bull.: Fr.) Pers. (Aphyllophoromycetideae) Extracts on Nerve Cells in Vitro

Volume 9, Edição 1, 2007, pp. 15-28
DOI: 10.1615/IntJMedMushr.v9.i1.30
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RESUMO

The neurotropic and trophic effect of extract obtained from the edible and medicinal mushroom Hericium erinaceus on nerve cells was studied. Spike reactions of hippocampal neurons during application of H. erinaceus fruiting bodies extract were studied on rat brain slices in vitro, using whole-cell patch clamp recording. Spike activity was inhibited in a concentration-dependent, reversible manner in 34%−90% of studied neurons by extracts obtained with ethanol, ether, or broth. Extract suppressed the excitation of neurons caused by L-glutamic acid application. The assumption is made that the H. erinaceus extract contains substances that may activate receptors that cause an inhibition of spike activity. The inhibitory effect of extract was not induced by GABA and serotonin receptor activation or activation of M- and N-cholinoreceptors. Inhibition of spike activity was caused by hyperpolarization of the neuronal membrane during extract application. The hyperpolarization was accompanied by an increase of apamin-sensitive Ca-activated K+ current (IAHP) and apamin-insensitive, slow Ca-activated K+ current (sIAHP), but it was not caused by an increase of inward rectifier K+ current (I(ir)) or by changes of hyperpolarization-activated cationic currents (I(h)). The effect of the extract was observed in the presence of tetrodotoxin, suggesting that the extract acts postsynaptically. Extract application did not suppress biochemical processes in cell respiratory circuits. The extract did not affect the regenerating abilities of the neurons and glial cells of the cerebellum and hippocampus. It was demonstrated that the H. erinaceus extract concentrate exerted neurotropic action and improved the myelination process in the mature myelinating fibers, did not affect nerve cell growth in vitro, and did not evoke a toxic effect or nerve cell damage.

CITADO POR
  1. Wong Kah-Hui, Naidu Murali, David Pamela, Abdulla Mahmood Ameen, Abdullah Noorlidah, Kuppusamy Umah Rani, Sabaratnam Vikineswary, Peripheral Nerve Regeneration Following Crush Injury to Rat Peroneal Nerve by Aqueous Extract of Medicinal MushroomHericium erinaceus(Bull.: Fr) Pers. (Aphyllophoromycetideae), Evidence-Based Complementary and Alternative Medicine, 2011, 2011. Crossref

  2. De Silva Dilani D., Rapior Sylvie, Sudarman Enge, Stadler Marc, Xu Jianchu, Aisyah Alias S., Hyde Kevin D., Bioactive metabolites from macrofungi: ethnopharmacology, biological activities and chemistry, Fungal Diversity, 62, 1, 2013. Crossref

  3. Wong Kah-Hui, Kanagasabapathy Gowri, Naidu Murali, David Pamela, Sabaratnam Vikineswary, Hericium erinaceus (Bull.: Fr.) Pers., a medicinal mushroom, activates peripheral nerve regeneration, Chinese Journal of Integrative Medicine, 22, 10, 2016. Crossref

  4. Wang Mingxing, Gao Yang, Xu Duoduo, Konishi Tetsuya, Gao Qipin, Hericium erinaceus (Yamabushitake): a unique resource for developing functional foods and medicines, Food Funct., 5, 12, 2014. Crossref

  5. Jiang Shengjuan, Wang Songhua, Sun Yujun, Zhang Qiang, Medicinal properties of Hericium erinaceus and its potential to formulate novel mushroom-based pharmaceuticals, Applied Microbiology and Biotechnology, 98, 18, 2014. Crossref

  6. Phan Chia-Wei, David Pamela, Naidu Murali, Wong Kah-Hui, Sabaratnam Vikineswary, Therapeutic potential of culinary-medicinal mushrooms for the management of neurodegenerative diseases: diversity, metabolite, and mechanism, Critical Reviews in Biotechnology, 35, 3, 2015. Crossref

  7. Grace Jeanne, Mudge Kenneth W., Production of Hericium sp. (Lion’s Mane) mushrooms on totem logs in a forest farming system, Agroforestry Systems, 89, 3, 2015. Crossref

  8. Thongbai Benjarong, Rapior Sylvie, Hyde Kevin D., Wittstein Kathrin, Stadler Marc, Hericium erinaceus, an amazing medicinal mushroom, Mycological Progress, 14, 10, 2015. Crossref

  9. Rahman Mohammad Azizur, Abdullah Noorlidah, Aminudin Norhaniza, Interpretation of mushroom as a common therapeutic agent for Alzheimer’s disease and cardiovascular diseases, Critical Reviews in Biotechnology, 36, 6, 2016. Crossref

  10. Phan Chia-Wei, David Pamela, Sabaratnam Vikineswary, Edible and Medicinal Mushrooms: Emerging Brain Food for the Mitigation of Neurodegenerative Diseases, Journal of Medicinal Food, 20, 1, 2017. Crossref

  11. Sabaratnam Vikineswary, Phan Chia-Wei, Neuroactive Components of Culinary and Medicinal Mushrooms With Potential to Mitigate Age-Related Neurodegenerative Diseases, in Discovery and Development of Neuroprotective Agents from Natural Products, 2018. Crossref

  12. WONG Kah-Hui, KANAGASABAPATHY Gowri, BAKAR Robiah, PHAN Chia-Wei, SABARATNAM Vikineswary, Restoration of sensory dysfunction following peripheral nerve injury by the polysaccharide from culinary and medicinal mushroom, Hericium erinaceus (Bull.: Fr.) Pers. through its neuroregenerative action, Food Science and Technology, 35, 4, 2015. Crossref

  13. Dasgupta Adhiraj, Acharya Krishnendu, Mushrooms: an emerging resource for therapeutic terpenoids, 3 Biotech, 9, 10, 2019. Crossref

  14. Gao Yang, Zheng Wei, Wang Mingxing, Xiao Xulang, Gao Miaomiao, Gao Qipin, Xu Duoduo, Molecular properties, structure, and antioxidant activities of the oligosaccharide Hep‐2 isolated from cultured mycelium of Hericium erinaceus , Journal of Food Biochemistry, 43, 9, 2019. Crossref

  15. Azeem Uzma, Hakeem Khalid Rehman, Ali M., Bioactive Constituents and Pharmacological Activities, in Fungi for Human Health, 2020. Crossref

  16. Kobayashi Shoji, Tamura Tomoki, Koshishiba Mizuho, Yasumoto Takeshi, Shimizu Satoshi, Kintaka Tomoki, Nagai Kaoru, Total Synthesis, Structure Revision, and Neuroprotective Effect of Hericenones C–H and Their Derivatives, The Journal of Organic Chemistry, 86, 3, 2021. Crossref

  17. Yamashina Kota , Yamamoto Shinji , Matsumoto Masako , Iwasa Kensuke , Takeda Nonoka , Haruta Chikara , Maruyama Kei , Shimizu Kuniyoshi , Yoshikawa Keisuke, Suppressive Effect of Fruiting Bodies of Medicinal Mushrooms on Demyelination and Motor Dysfunction in a Cuprizone-Induced Multiple Sclerosis Mouse Model , International Journal of Medicinal Mushrooms, 24, 9, 2022. Crossref

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