Publicou 12 edições por ano
ISSN Imprimir: 1521-9437
ISSN On-line: 1940-4344
Indexed in
Specificity of the Immunomodulating Activity of Sasa veitchii (Japanese Folk Medicine Kumazasa) to Fungal Polysaccharides
RESUMO
Many plant extracts are used as well-known folk medicines and exhibit various biological activities that are beneficial to human health. These extracts contain polysaccharides, and some are pathogen-associated molecular patterns (PAMPs) that stimulate innate as well as acquired immune systems. In the present study, the cooperative effects of PAMPs and bamboo water-soluble methanol precipitation (BWMP) in a macromolecular fraction of the hot water extract of Sasa veitchii (in Japanese folk medicine, known as Kumazasa; family Poaceae) were analyzed in vitro using the spleen or bone marrow cells of mice. The splenocytes of male DBA/2 and C57BL/6 mice were cultured with BWMP in the presence or absence of PAMPs, and responses were assessed by measuring cytokines. BWMP inhibited the production of interferon gamma (IFN−γ) by not only toll like receptors (TLRs), but also the C-type lectin receptors (CLRs) dectin-1 and dectin-2. BWMP also inhibited the autologous production of IFN−γ in the splenocyte culture. These results suggested that BWMP may inhibit the signaling pathways of PAMPs, but not ligand-receptor interactions. In contrast, BWMP did not inhibit the production of cytokines by dendritic cells. These results indicated that the inhibition of IFN−γ by BWMP was mediated through the cell-to-cell interactions of splenic cells during cultivation.
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B. Wróblewska Katarzyna, C.S. de Oliveira Danielle, Tereza Grombone-Guaratini Maria, Roberto H. Moreno Paulo, Medicinal Properties of Bamboos, in Pharmacognosy - Medicinal Plants, 2019. Crossref
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Li Wen-Juan, Tang Xiao-Fang, Shuai Xiao-Xue, Jiang Cheng-Jia, Liu Xiang, Wang Le-Feng, Yao Yu-Fei, Nie Shao-Ping, Xie Ming-Yong, Mannose Receptor Mediates the Immune Response to Ganoderma atrum Polysaccharides in Macrophages, Journal of Agricultural and Food Chemistry, 65, 2, 2017. Crossref
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Gagliano Janayne, Anselmo-Moreira Fernanda, Sala-Carvalho Wilton Ricardo, Furlan Cláudia Maria, What is known about the medicinal potential of bamboo?, Advances in Traditional Medicine, 22, 3, 2022. Crossref