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International Journal of Medicinal Mushrooms
Fator do impacto: 1.423 FI de cinco anos: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Imprimir: 1521-9437
ISSN On-line: 1940-4344

Volumes:
Volume 22, 2020 Volume 21, 2019 Volume 20, 2018 Volume 19, 2017 Volume 18, 2016 Volume 17, 2015 Volume 16, 2014 Volume 15, 2013 Volume 14, 2012 Volume 13, 2011 Volume 12, 2010 Volume 11, 2009 Volume 10, 2008 Volume 9, 2007 Volume 8, 2006 Volume 7, 2005 Volume 6, 2004 Volume 5, 2003 Volume 4, 2002 Volume 3, 2001 Volume 2, 2000 Volume 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.2019030636
pages 413-428

Immunochemical Similarities in Polysaccharide Components of the Royal Sun Culinary-Medicinal Mushroom, Agaricus brasiliensis (Agaricomycetes), and Clinically Isolated Candida spp

Hiroaki Tanaka
Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan; Department of Pharmacy, Kyorin University Hospital, Tokyo, Japan
Chiho Yanai
Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan
Ken-ichi Ishibashi
Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan
Daisuke Yamanaka
Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan
Yoshiyuki Adachi
Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan
Koji Araki
Department of Laboratory Medicine, Kyorin University Hospital, Tokyo, Japan
Shota Yonetani
Department of Laboratory Medicine, Kyorin University Hospital, Tokyo, Japan
Hiroaki Ohnishi
Department of Laboratory Medicine, Kyorin University Hospital, Tokyo, Japan
Takao Shinohara
Department of Pharmacy, Kyorin University Hospital, Tokyo, Japan
Naohito Ohno
Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan

RESUMO

Candidiasis is a common fungal infection caused by yeasts belonging to the genus Candida and includes mucosal candidiasis, cutaneous candidiasis, and systemic candidiasis. Candida yeasts generally present in healthy humans as components of the microbiome. The host defense system typically protects the surface barriers of the body by various components; however, a failure in this system may result in candidiasis. Agaricus brasiliensis is a well-known health food that induces the production of protective antibodies against fungal β-glucans. In the present study, we examined immunochemical similarities in the polysaccharide components of clinically isolated Candida spp. and A. brasiliensis. The results obtained showed that the hot water extract of A. brasiliensis (AgHWE) strongly reacted with those of clinically isolated Candida spp. (CAHWE). Furthermore, not only β-glucans but also mannan were identified as cross-reactive antigens. These results strongly suggest that A. brasiliensis is capable of enhancing protective immunity against Candida spp.